Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.

N. Boontje; D. Merkus; R. Zaremba; A.M.G. Versteilen; M. de Waard; G. Mearini; V.J. de Beer; L. Carrier; L.A. Walker; H.W.M. Niessen; D. Dobrev; G.J.M. Stienen; D.J. Duncker; J. van der Velden

doi:https://doi.org/10.1016/j.yjmcc.2010.12.002

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.

N. Boontje, D. Merkus, R. Zaremba, A.M.G. Versteilen, M. de Waard, G. Mearini, V.J. de Beer, L. Carrier, L.A. Walker, H.W.M. Niessen, D. Dobrev, G.J.M. Stienen, D.J. Duncker, J. van der Velden

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Previously we showed that left ventricular (LV) responsiveness to exercise-induced increases in noradrenaline was blunted in pigs with a recent myocardial infarction (MI) [van der Velden et al. Circ Res. 2004], consistent with perturbed β-adrenergic receptor (β-AR) signaling. Here we tested the hypothesis that abnormalities at the myofilament level underlie impaired LV responsiveness to catecholamines in MI. Myofilament function and protein composition were studied in remote LV biopsies taken at baseline and during dobutamine stimulation 3weeks after MI or sham. Single permeabilized cardiomyocytes demonstrated reduced maximal force (F

Original language	English
Pages (from-to)	487-499
Journal	Journal of molecular and cellular cardiology
Volume	50
DOIs	https://doi.org/10.1016/j.yjmcc.2010.12.002
Publication status	Published - 2011

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Cite this

Boontje, N., Merkus, D., Zaremba, R., Versteilen, A. M. G., de Waard, M., Mearini, G., de Beer, V. J., Carrier, L., Walker, L. A., Niessen, H. W. M., Dobrev, D., Stienen, G. J. M., Duncker, D. J., & van der Velden, J. (2011). Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium. Journal of molecular and cellular cardiology, 50, 487-499. https://doi.org/10.1016/j.yjmcc.2010.12.002

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title = "Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.",

abstract = "Previously we showed that left ventricular (LV) responsiveness to exercise-induced increases in noradrenaline was blunted in pigs with a recent myocardial infarction (MI) [van der Velden et al. Circ Res. 2004], consistent with perturbed β-adrenergic receptor (β-AR) signaling. Here we tested the hypothesis that abnormalities at the myofilament level underlie impaired LV responsiveness to catecholamines in MI. Myofilament function and protein composition were studied in remote LV biopsies taken at baseline and during dobutamine stimulation 3weeks after MI or sham. Single permeabilized cardiomyocytes demonstrated reduced maximal force (F",

author = "N. Boontje and D. Merkus and R. Zaremba and A.M.G. Versteilen and {de Waard}, M. and G. Mearini and {de Beer}, V.J. and L. Carrier and L.A. Walker and H.W.M. Niessen and D. Dobrev and G.J.M. Stienen and D.J. Duncker and {van der Velden}, J.",

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Boontje, N, Merkus, D, Zaremba, R, Versteilen, AMG, de Waard, M, Mearini, G, de Beer, VJ, Carrier, L, Walker, LA, Niessen, HWM, Dobrev, D, Stienen, GJM, Duncker, DJ & van der Velden, J 2011, 'Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.', Journal of molecular and cellular cardiology, vol. 50, pp. 487-499. https://doi.org/10.1016/j.yjmcc.2010.12.002

TY - JOUR

T1 - Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.

AU - Boontje, N.

AU - Merkus, D.

AU - Zaremba, R.

AU - Versteilen, A.M.G.

AU - de Waard, M.

AU - Mearini, G.

AU - de Beer, V.J.

AU - Carrier, L.

AU - Walker, L.A.

AU - Niessen, H.W.M.

AU - Dobrev, D.

AU - Stienen, G.J.M.

AU - Duncker, D.J.

AU - van der Velden, J.

PY - 2011

Y1 - 2011

N2 - Previously we showed that left ventricular (LV) responsiveness to exercise-induced increases in noradrenaline was blunted in pigs with a recent myocardial infarction (MI) [van der Velden et al. Circ Res. 2004], consistent with perturbed β-adrenergic receptor (β-AR) signaling. Here we tested the hypothesis that abnormalities at the myofilament level underlie impaired LV responsiveness to catecholamines in MI. Myofilament function and protein composition were studied in remote LV biopsies taken at baseline and during dobutamine stimulation 3weeks after MI or sham. Single permeabilized cardiomyocytes demonstrated reduced maximal force (F

AB - Previously we showed that left ventricular (LV) responsiveness to exercise-induced increases in noradrenaline was blunted in pigs with a recent myocardial infarction (MI) [van der Velden et al. Circ Res. 2004], consistent with perturbed β-adrenergic receptor (β-AR) signaling. Here we tested the hypothesis that abnormalities at the myofilament level underlie impaired LV responsiveness to catecholamines in MI. Myofilament function and protein composition were studied in remote LV biopsies taken at baseline and during dobutamine stimulation 3weeks after MI or sham. Single permeabilized cardiomyocytes demonstrated reduced maximal force (F

U2 - https://doi.org/10.1016/j.yjmcc.2010.12.002

DO - https://doi.org/10.1016/j.yjmcc.2010.12.002

M3 - Article

C2 - 21156182

SN - 0022-2828

VL - 50

SP - 487

EP - 499

JO - Journal of molecular and cellular cardiology

JF - Journal of molecular and cellular cardiology

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