TY - JOUR
T1 - ENIGMA's simple seven
T2 - Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury
AU - Caeyenberghs, Karen
AU - Imms, Phoebe
AU - Irimia, Andrei
AU - Monti, Martin M.
AU - Esopenko, Carrie
AU - de Souza, Nicola L.
AU - Dominguez D, Juan F.
AU - Newsome, Mary R.
AU - Dobryakova, Ekaterina
AU - Cwiek, Andrew
AU - Mullin, Hollie A. C.
AU - Kim, Nicholas J.
AU - Mayer, Andrew R.
AU - Adamson, Maheen M.
AU - Bickart, Kevin
AU - Breedlove, Katherine M.
AU - Dennis, Emily L.
AU - Disner, Seth G.
AU - Haswell, Courtney
AU - Hodges, Cooper B.
AU - Hoskinson, Kristen R.
AU - Johnson, Paula K.
AU - Königs, Marsh
AU - Li, Lucia M.
AU - Liebel, Spencer W.
AU - Livny, Abigail
AU - Morey, Rajendra A.
AU - Muir, Alexandra M.
AU - Olsen, Alexander
AU - Razi, Adeel
AU - Su, Matthew
AU - Tate, David F.
AU - Velez, Carmen
AU - Wilde, Elisabeth A.
AU - Zielinski, Brandon A.
AU - Thompson, Paul M.
AU - Hillary, Frank G.
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disorders, such as traumatic brain injury (TBI). While rsfMRI holds unparalleled promise in systems neurosciences, its acquisition and analytical methodology across research groups is variable, resulting in a literature that is challenging to integrate and interpret. The focus of this narrative review is to address the primary methodological issues including investigator decision points in the application of rsfMRI to study the consequences of TBI. As part of the ENIGMA Brain Injury working group, we have collaborated to identify a minimum set of recommendations that are designed to produce results that are reliable, harmonizable, and reproducible for the TBI imaging research community. Part one of this review provides the results of a literature search of current rsfMRI studies of TBI, highlighting key design considerations and data processing pipelines. Part two outlines seven data acquisition, processing, and analysis recommendations with the goal of maximizing study reliability and between-site comparability, while preserving investigator autonomy. Part three summarizes new directions and opportunities for future rsfMRI studies in TBI patients. The goal is to galvanize the TBI community to gain consensus for a set of rigorous and reproducible methods, and to increase analytical transparency and data sharing to address the reproducibility crisis in the field.
AB - Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disorders, such as traumatic brain injury (TBI). While rsfMRI holds unparalleled promise in systems neurosciences, its acquisition and analytical methodology across research groups is variable, resulting in a literature that is challenging to integrate and interpret. The focus of this narrative review is to address the primary methodological issues including investigator decision points in the application of rsfMRI to study the consequences of TBI. As part of the ENIGMA Brain Injury working group, we have collaborated to identify a minimum set of recommendations that are designed to produce results that are reliable, harmonizable, and reproducible for the TBI imaging research community. Part one of this review provides the results of a literature search of current rsfMRI studies of TBI, highlighting key design considerations and data processing pipelines. Part two outlines seven data acquisition, processing, and analysis recommendations with the goal of maximizing study reliability and between-site comparability, while preserving investigator autonomy. Part three summarizes new directions and opportunities for future rsfMRI studies in TBI patients. The goal is to galvanize the TBI community to gain consensus for a set of rigorous and reproducible methods, and to increase analytical transparency and data sharing to address the reproducibility crisis in the field.
KW - Functional MRI
KW - Functional connectivity
KW - Lesions
KW - Reproducibility
KW - Resting state fMRI
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85188788525&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2024.103585
DO - 10.1016/j.nicl.2024.103585
M3 - Review article
C2 - 38531165
SN - 2213-1582
VL - 42
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103585
ER -