Enrichment of CCR6+CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19

Amsterdam UMC COVID study group

Research output: Contribution to journalComment/Letter to the editorAcademic

20 Citations (Scopus)

Abstract

Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. ​.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalEuropean journal of immunology
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • CCL20
  • CCR6
  • COVID-19
  • T cells

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