TY - JOUR
T1 - Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice
AU - Leendertse, Masja
AU - Heikens, Esther
AU - Wijnands, Lucas M.
AU - van Luit-Asbroek, Miranda
AU - Teske, Gwendoline J. D.
AU - Roelofs, Joris J. T. H.
AU - Bonten, Marc J. M.
AU - van der Poll, Tom
AU - Willems, Rob J. L.
PY - 2009
Y1 - 2009
N2 - The role that the enterococcal surface protein Esp plays in the capacity of Enterococcus faecium to adhere to uroepithelial cells and the role that it plays in urinary tract infection and peritonitis was investigated in vitro and in vivo, respectively, using Esp-expressing E. faecium (E1162) and its isogenic Esp-deficient mutant (E1162 Delta esp). Esp expression enhanced in vitro binding to bladder and kidney epithelial cells. In mice, higher numbers of E1162 were cultured from kidneys and bladders after the induction of urinary tract infection, compared with E1162 Delta esp numbers. This was accompanied by a higher frequency of bacteremia, higher cytokine levels in kidney tissue, and renal insufficiency. Esp had no effect on the course of E. faecium peritonitis
AB - The role that the enterococcal surface protein Esp plays in the capacity of Enterococcus faecium to adhere to uroepithelial cells and the role that it plays in urinary tract infection and peritonitis was investigated in vitro and in vivo, respectively, using Esp-expressing E. faecium (E1162) and its isogenic Esp-deficient mutant (E1162 Delta esp). Esp expression enhanced in vitro binding to bladder and kidney epithelial cells. In mice, higher numbers of E1162 were cultured from kidneys and bladders after the induction of urinary tract infection, compared with E1162 Delta esp numbers. This was accompanied by a higher frequency of bacteremia, higher cytokine levels in kidney tissue, and renal insufficiency. Esp had no effect on the course of E. faecium peritonitis
U2 - https://doi.org/10.1086/605609
DO - https://doi.org/10.1086/605609
M3 - Article
C2 - 19702507
SN - 0022-1899
VL - 200
SP - 1162
EP - 1165
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 7
ER -