TY - JOUR
T1 - Environmental regulation of valvulogenesis: implications for tissue engineering
AU - Riem Vis, Paul W.
AU - Kluin, Jolanda
AU - Sluijter, Joost P. G.
AU - van Herwerden, Lex A.
AU - Bouten, Carlijn V. C.
PY - 2011
Y1 - 2011
N2 - Ongoing research efforts aim at improving the creation of tissue-engineered heart valves for in vivo systemic application. Hence, in vitro studies concentrate on optimising culture protocols incorporating biological as well as biophysical stimuli for tissue development. Important lessons can be drawn from valvulogenesis to mimic natural valve development in vitro. Here, we review the up-to-date status of valvulogenesis, focussing on the biomolecular and biophysical regulation of semilunar valve development. In addition, we discuss potential benefits of incorporating concepts derived from valvulogenesis, as well as alternative approaches, in tissue-engineering protocols, to improve in vitro valve development. The combined efforts from clinicians, cell biologists and engineers are required to implement and evaluate these approaches to achieve optimised protocols for heart-valve tissue engineering. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier By. All rights reserved
AB - Ongoing research efforts aim at improving the creation of tissue-engineered heart valves for in vivo systemic application. Hence, in vitro studies concentrate on optimising culture protocols incorporating biological as well as biophysical stimuli for tissue development. Important lessons can be drawn from valvulogenesis to mimic natural valve development in vitro. Here, we review the up-to-date status of valvulogenesis, focussing on the biomolecular and biophysical regulation of semilunar valve development. In addition, we discuss potential benefits of incorporating concepts derived from valvulogenesis, as well as alternative approaches, in tissue-engineering protocols, to improve in vitro valve development. The combined efforts from clinicians, cell biologists and engineers are required to implement and evaluate these approaches to achieve optimised protocols for heart-valve tissue engineering. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier By. All rights reserved
U2 - https://doi.org/10.1016/j.ejcts.2010.05.032
DO - https://doi.org/10.1016/j.ejcts.2010.05.032
M3 - Review article
C2 - 20637649
SN - 1010-7940
VL - 39
SP - 8
EP - 17
JO - European journal of cardio-thoracic surgery
JF - European journal of cardio-thoracic surgery
IS - 1
ER -