Enzymology of the Carnitine Biosynthesis Pathway

Karin Strijbis; Frédéric M. Vaz; Ben Distel

doi:https://doi.org/10.1002/iub.323

Enzymology of the Carnitine Biosynthesis Pathway

Karin Strijbis, Frédéric M. Vaz, Ben Distel

Research output: Contribution to journal › Review article › Academic › peer-review

111 Citations (Scopus)

Abstract

The water-soluble zwitterion carnitine is an essential metabolite in eukaryotes required for fatty acid oxidation as it functions as a carrier during transfer of activated acyl and acetyl groups across intracellular membranes. Most eukaryotes are able to synthesize carnitine endogenously, besides their capacity to take up carnitine from the diet or extracellular medium through plasma membrane transporters. This review discusses the current knowledge on carnitine homeostasis with special emphasis on the enzymology of the four steps of the carnitine biosynthesis pathway. (C) 2010 IUBMB IUBMB Life, 62(5): 357-362, 2010

Original language	English
Pages (from-to)	357-362
Journal	IUBMB life
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/iub.323
Publication status	Published - 2010

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https://doi.org/10.1002/iub.323

Cite this

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AB - The water-soluble zwitterion carnitine is an essential metabolite in eukaryotes required for fatty acid oxidation as it functions as a carrier during transfer of activated acyl and acetyl groups across intracellular membranes. Most eukaryotes are able to synthesize carnitine endogenously, besides their capacity to take up carnitine from the diet or extracellular medium through plasma membrane transporters. This review discusses the current knowledge on carnitine homeostasis with special emphasis on the enzymology of the four steps of the carnitine biosynthesis pathway. (C) 2010 IUBMB IUBMB Life, 62(5): 357-362, 2010

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DO - https://doi.org/10.1002/iub.323

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