Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry

Wim Laurens; Dries Deleersnijder; Amelie Dendooven; Evelyne Lerut; An S. De Vriese; Tom Dejagere; Mark Helbert; Rachel Hellemans; Priyanka Koshy; Bart Maes; Lissa Pipeleers; Amaryllis H. Van Craenenbroeck; Steven Van Laecke; Johan Vande Walle; Marie M. Coutteneye; Johan De Meester; Ben Sprangers; An De Vriese; Anja De Rycke; Anne Marie Bogaert; Annemie Woestenburg; Bart Denys; Bart Maes; Domien Peeters; Hilde Vanbelleghem; Jan Donck; Johan Scharpe; Nele De Clippeleir; Joris Vanparys; Karen Meyvis; Kurt Vandepitte; Liza Maria Reyns; Luc Verresen; Marc Decupere; Mark Helbert; Miranda Zeegers; Nathalie Neirynck; Pascale Bernaert; Tom Dejagere; Wim Lemahieu; Ben Sprangers; Lissa Pipeleers; Rachel Hellemans; Steven Van Laecke; Elena Levtchenko; Sevasti Karamaria; Koen Van Hoeck; Dominique Trouet; Reiner Mauel; Amelie Dendooven; Anne Hoorens; Jo Van Dorpe; Marleen Praet; Caroline Geers; Evelyne Lerut; Priyanka Koshy; Tania Roskams; Selda Aydin; Vasiliki Siozopoulou; Anne Marie Schelfhout; Hendrik De Raeve; Edwin Steenkiste; Francesca Dedeurwaerdere; Ignace Dalle; Kristof Cokelaere; Stijn Deloose; Pascale De Paepe; Peter Van Eyken

doi:https://doi.org/10.1093/ckj/sfac033

Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry

Wim Laurens, Dries Deleersnijder, Amelie Dendooven, Evelyne Lerut, An S. De Vriese, Tom Dejagere, Mark Helbert, Rachel Hellemans, Priyanka Koshy, Bart Maes, Lissa Pipeleers, Amaryllis H. Van Craenenbroeck, Steven Van Laecke, Johan Vande Walle, Marie M. Coutteneye, Johan De Meester, Ben Sprangers, An De Vriese, Anja De Rycke, Anne Marie BogaertAnnemie Woestenburg, Bart Denys, Bart Maes, Domien Peeters, Hilde Vanbelleghem, Jan Donck, Johan Scharpe, Nele De Clippeleir, Joris Vanparys, Karen Meyvis, Kurt Vandepitte, Liza Maria Reyns, Luc Verresen, Marc Decupere, Mark Helbert, Miranda Zeegers, Nathalie Neirynck, Pascale Bernaert, Tom Dejagere, Wim Lemahieu, Ben Sprangers, Lissa Pipeleers, Rachel Hellemans, Steven Van Laecke, Elena Levtchenko, Sevasti Karamaria, Koen Van Hoeck, Dominique Trouet, Reiner Mauel, Amelie Dendooven, Anne Hoorens, Jo Van Dorpe, Marleen Praet, Caroline Geers, Evelyne Lerut, Priyanka Koshy, Tania Roskams, Selda Aydin, Vasiliki Siozopoulou, Anne Marie Schelfhout, Hendrik De Raeve, Edwin Steenkiste, Francesca Dedeurwaerdere, Ignace Dalle, Kristof Cokelaere, Stijn Deloose, Pascale De Paepe, Peter Van Eyken

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distribution and incidence rate of biopsied kidney disease in adults in Flanders. Methods: From January 2017 to December 2019, a total of 2054 adult first native kidney biopsies were included. A 'double diagnostic coding' strategy was used, in which every biopsy sample received a histopathological and final clinical diagnosis. Frequency distribution and incidence rate of both diagnoses were reported and compared with other European registries. Results: The median age at biopsy was 61.1 years (interquartile range, 46.1-71.7); male patients were more prevalent (62.1%) and biopsy incidence rate was 129.3 per million persons per year. Immunoglobulin A nephropathy was the most frequently diagnosed kidney disease (355 biopsies, 17.3% of total) with a similar frequency as in previously published European registries. The frequency of tubulointerstitial nephritis (220 biopsies, 10.7%) and diabetic kidney disease (154 biopsies, 7.5%) was remarkably higher, which may be attributed to changes in disease incidence as well as biopsy practices. Discordances between histopathological and final clinical diagnoses were noted and indicate areas for improvement in diagnostic coding systems. Conclusions: The FCGG registry, with its 'double diagnostic coding' strategy, provides useful population-based epidemiological data on a large Western European population and allows subgroup selection for future research.

Original language	English
Pages (from-to)	1361-1372
Number of pages	12
Journal	Clinical Kidney Journal
Volume	15
Issue number	7
DOIs	https://doi.org/10.1093/ckj/sfac033
Publication status	Published - 1 Jul 2022
Externally published	Yes

Keywords

biopsy
epidemiology
frequency
incidence
native kidney
observational
pathology
registry

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https://doi.org/10.1093/ckj/sfac033

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Laurens, W., Deleersnijder, D., Dendooven, A., Lerut, E., De Vriese, A. S., Dejagere, T., Helbert, M., Hellemans, R., Koshy, P., Maes, B., Pipeleers, L., Van Craenenbroeck, A. H., Van Laecke, S., Vande Walle, J., Coutteneye, M. M., De Meester, J., Sprangers, B., De Vriese, A., De Rycke, A., ... Van Eyken, P. (2022). Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry. Clinical Kidney Journal, 15(7), 1361-1372. https://doi.org/10.1093/ckj/sfac033

@article{f8711935b9e04f1a8f69ca613a419453,

title = "Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry",

abstract = "Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distribution and incidence rate of biopsied kidney disease in adults in Flanders. Methods: From January 2017 to December 2019, a total of 2054 adult first native kidney biopsies were included. A 'double diagnostic coding' strategy was used, in which every biopsy sample received a histopathological and final clinical diagnosis. Frequency distribution and incidence rate of both diagnoses were reported and compared with other European registries. Results: The median age at biopsy was 61.1 years (interquartile range, 46.1-71.7); male patients were more prevalent (62.1%) and biopsy incidence rate was 129.3 per million persons per year. Immunoglobulin A nephropathy was the most frequently diagnosed kidney disease (355 biopsies, 17.3% of total) with a similar frequency as in previously published European registries. The frequency of tubulointerstitial nephritis (220 biopsies, 10.7%) and diabetic kidney disease (154 biopsies, 7.5%) was remarkably higher, which may be attributed to changes in disease incidence as well as biopsy practices. Discordances between histopathological and final clinical diagnoses were noted and indicate areas for improvement in diagnostic coding systems. Conclusions: The FCGG registry, with its 'double diagnostic coding' strategy, provides useful population-based epidemiological data on a large Western European population and allows subgroup selection for future research.",

keywords = "biopsy, epidemiology, frequency, incidence, native kidney, observational, pathology, registry",

author = "Wim Laurens and Dries Deleersnijder and Amelie Dendooven and Evelyne Lerut and {De Vriese}, {An S.} and Tom Dejagere and Mark Helbert and Rachel Hellemans and Priyanka Koshy and Bart Maes and Lissa Pipeleers and {Van Craenenbroeck}, {Amaryllis H.} and {Van Laecke}, Steven and {Vande Walle}, Johan and Coutteneye, {Marie M.} and {De Meester}, Johan and Ben Sprangers and {De Vriese}, An and {De Rycke}, Anja and Bogaert, {Anne Marie} and Annemie Woestenburg and Bart Denys and Bart Maes and Domien Peeters and Hilde Vanbelleghem and Jan Donck and Johan Scharpe and {De Clippeleir}, Nele and Joris Vanparys and Karen Meyvis and Kurt Vandepitte and Reyns, {Liza Maria} and Luc Verresen and Marc Decupere and Mark Helbert and Miranda Zeegers and Nathalie Neirynck and Pascale Bernaert and Tom Dejagere and Wim Lemahieu and Ben Sprangers and Lissa Pipeleers and Rachel Hellemans and {Van Laecke}, Steven and Elena Levtchenko and Sevasti Karamaria and {Van Hoeck}, Koen and Dominique Trouet and Reiner Mauel and Amelie Dendooven and Anne Hoorens and {Van Dorpe}, Jo and Marleen Praet and Caroline Geers and Evelyne Lerut and Priyanka Koshy and Tania Roskams and Selda Aydin and Vasiliki Siozopoulou and Schelfhout, {Anne Marie} and {De Raeve}, Hendrik and Edwin Steenkiste and Francesca Dedeurwaerdere and Ignace Dalle and Kristof Cokelaere and Stijn Deloose and {De Paepe}, Pascale and {Van Eyken}, Peter",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of the ERA.",

year = "2022",

month = jul,

day = "1",

doi = "https://doi.org/10.1093/ckj/sfac033",

language = "English",

volume = "15",

pages = "1361--1372",

journal = "Clinical Kidney Journal",

issn = "2048-8505",

publisher = "Oxford University Press",

number = "7",

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Laurens, W, Deleersnijder, D, Dendooven, A, Lerut, E, De Vriese, AS, Dejagere, T, Helbert, M, Hellemans, R, Koshy, P, Maes, B, Pipeleers, L, Van Craenenbroeck, AH, Van Laecke, S, Vande Walle, J, Coutteneye, MM, De Meester, J, Sprangers, B, De Vriese, A, De Rycke, A, Bogaert, AM, Woestenburg, A, Denys, B, Maes, B, Peeters, D, Vanbelleghem, H, Donck, J, Scharpe, J, De Clippeleir, N, Vanparys, J, Meyvis, K, Vandepitte, K, Reyns, LM, Verresen, L, Decupere, M, Helbert, M, Zeegers, M, Neirynck, N, Bernaert, P, Dejagere, T, Lemahieu, W, Sprangers, B, Pipeleers, L, Hellemans, R, Van Laecke, S, Levtchenko, E, Karamaria, S, Van Hoeck, K, Trouet, D, Mauel, R, Dendooven, A, Hoorens, A, Van Dorpe, J, Praet, M, Geers, C, Lerut, E, Koshy, P, Roskams, T, Aydin, S, Siozopoulou, V, Schelfhout, AM, De Raeve, H, Steenkiste, E, Dedeurwaerdere, F, Dalle, I, Cokelaere, K, Deloose, S, De Paepe, P & Van Eyken, P 2022, 'Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry', Clinical Kidney Journal, vol. 15, no. 7, pp. 1361-1372. https://doi.org/10.1093/ckj/sfac033

TY - JOUR

T1 - Epidemiology of native kidney disease in Flanders

T2 - Results from the FCGG kidney biopsy registry

AU - Laurens, Wim

AU - Deleersnijder, Dries

AU - Dendooven, Amelie

AU - Lerut, Evelyne

AU - De Vriese, An S.

AU - Dejagere, Tom

AU - Helbert, Mark

AU - Hellemans, Rachel

AU - Koshy, Priyanka

AU - Maes, Bart

AU - Pipeleers, Lissa

AU - Van Craenenbroeck, Amaryllis H.

AU - Van Laecke, Steven

AU - Vande Walle, Johan

AU - Coutteneye, Marie M.

AU - De Meester, Johan

AU - Sprangers, Ben

AU - De Vriese, An

AU - De Rycke, Anja

AU - Bogaert, Anne Marie

AU - Woestenburg, Annemie

AU - Denys, Bart

AU - Maes, Bart

AU - Peeters, Domien

AU - Vanbelleghem, Hilde

AU - Donck, Jan

AU - Scharpe, Johan

AU - De Clippeleir, Nele

AU - Vanparys, Joris

AU - Meyvis, Karen

AU - Vandepitte, Kurt

AU - Reyns, Liza Maria

AU - Verresen, Luc

AU - Decupere, Marc

AU - Helbert, Mark

AU - Zeegers, Miranda

AU - Neirynck, Nathalie

AU - Bernaert, Pascale

AU - Dejagere, Tom

AU - Lemahieu, Wim

AU - Sprangers, Ben

AU - Pipeleers, Lissa

AU - Hellemans, Rachel

AU - Van Laecke, Steven

AU - Levtchenko, Elena

AU - Karamaria, Sevasti

AU - Van Hoeck, Koen

AU - Trouet, Dominique

AU - Mauel, Reiner

AU - Dendooven, Amelie

AU - Hoorens, Anne

AU - Van Dorpe, Jo

AU - Praet, Marleen

AU - Geers, Caroline

AU - Lerut, Evelyne

AU - Koshy, Priyanka

AU - Roskams, Tania

AU - Aydin, Selda

AU - Siozopoulou, Vasiliki

AU - Schelfhout, Anne Marie

AU - De Raeve, Hendrik

AU - Steenkiste, Edwin

AU - Dedeurwaerdere, Francesca

AU - Dalle, Ignace

AU - Cokelaere, Kristof

AU - Deloose, Stijn

AU - De Paepe, Pascale

AU - Van Eyken, Peter

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distribution and incidence rate of biopsied kidney disease in adults in Flanders. Methods: From January 2017 to December 2019, a total of 2054 adult first native kidney biopsies were included. A 'double diagnostic coding' strategy was used, in which every biopsy sample received a histopathological and final clinical diagnosis. Frequency distribution and incidence rate of both diagnoses were reported and compared with other European registries. Results: The median age at biopsy was 61.1 years (interquartile range, 46.1-71.7); male patients were more prevalent (62.1%) and biopsy incidence rate was 129.3 per million persons per year. Immunoglobulin A nephropathy was the most frequently diagnosed kidney disease (355 biopsies, 17.3% of total) with a similar frequency as in previously published European registries. The frequency of tubulointerstitial nephritis (220 biopsies, 10.7%) and diabetic kidney disease (154 biopsies, 7.5%) was remarkably higher, which may be attributed to changes in disease incidence as well as biopsy practices. Discordances between histopathological and final clinical diagnoses were noted and indicate areas for improvement in diagnostic coding systems. Conclusions: The FCGG registry, with its 'double diagnostic coding' strategy, provides useful population-based epidemiological data on a large Western European population and allows subgroup selection for future research.

AB - Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distribution and incidence rate of biopsied kidney disease in adults in Flanders. Methods: From January 2017 to December 2019, a total of 2054 adult first native kidney biopsies were included. A 'double diagnostic coding' strategy was used, in which every biopsy sample received a histopathological and final clinical diagnosis. Frequency distribution and incidence rate of both diagnoses were reported and compared with other European registries. Results: The median age at biopsy was 61.1 years (interquartile range, 46.1-71.7); male patients were more prevalent (62.1%) and biopsy incidence rate was 129.3 per million persons per year. Immunoglobulin A nephropathy was the most frequently diagnosed kidney disease (355 biopsies, 17.3% of total) with a similar frequency as in previously published European registries. The frequency of tubulointerstitial nephritis (220 biopsies, 10.7%) and diabetic kidney disease (154 biopsies, 7.5%) was remarkably higher, which may be attributed to changes in disease incidence as well as biopsy practices. Discordances between histopathological and final clinical diagnoses were noted and indicate areas for improvement in diagnostic coding systems. Conclusions: The FCGG registry, with its 'double diagnostic coding' strategy, provides useful population-based epidemiological data on a large Western European population and allows subgroup selection for future research.

KW - biopsy

KW - epidemiology

KW - frequency

KW - incidence

KW - native kidney

KW - observational

KW - pathology

KW - registry

UR - http://www.scopus.com/inward/record.url?scp=85139786433&partnerID=8YFLogxK

U2 - https://doi.org/10.1093/ckj/sfac033

DO - https://doi.org/10.1093/ckj/sfac033

M3 - Article

C2 - 35756729

SN - 2048-8505

VL - 15

SP - 1361

EP - 1372

JO - Clinical Kidney Journal

JF - Clinical Kidney Journal

IS - 7

ER -

Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry

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Keywords

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