Epithelial lacrimal gland tumors: pathologic classification and current understanding

Ezekiel Weis; Jack Rootman; Thomas J. Joly; Kenneth W. Berean; Hind M. Al-Katan; Sylvia Pasternak; Giulio Bonavolontà; Diego Strianese; Peerooz Saeed; Kenneth A. Feldman; Sumalee Vangveeravong; Jocelyne S. Lapointe; Valerie A. White

doi:https://doi.org/10.1001/archophthalmol.2009.209

Epithelial lacrimal gland tumors: pathologic classification and current understanding

Ezekiel Weis, Jack Rootman, Thomas J. Joly, Kenneth W. Berean, Hind M. Al-Katan, Sylvia Pasternak, Giulio Bonavolontà, Diego Strianese, Peerooz Saeed, Kenneth A. Feldman, Sumalee Vangveeravong, Jocelyne S. Lapointe, Valerie A. White

Research output: Contribution to journal › Article › Academic › peer-review

103 Citations (Scopus)

Abstract

OBJECTIVE: To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. METHODS: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. RESULTS: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. CONCLUSIONS: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions

Original language	English
Pages (from-to)	1016-1028
Journal	Archives of ophthalmology
Volume	127
Issue number	8
DOIs	https://doi.org/10.1001/archophthalmol.2009.209
Publication status	Published - 2009

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https://doi.org/10.1001/archophthalmol.2009.209

Cite this

Weis, E., Rootman, J., Joly, T. J., Berean, K. W., Al-Katan, H. M., Pasternak, S., Bonavolontà, G., Strianese, D., Saeed, P., Feldman, K. A., Vangveeravong, S., Lapointe, J. S., & White, V. A. (2009). Epithelial lacrimal gland tumors: pathologic classification and current understanding. Archives of ophthalmology, 127(8), 1016-1028. https://doi.org/10.1001/archophthalmol.2009.209

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title = "Epithelial lacrimal gland tumors: pathologic classification and current understanding",

abstract = "OBJECTIVE: To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. METHODS: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. RESULTS: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. CONCLUSIONS: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions",

author = "Ezekiel Weis and Jack Rootman and Joly, {Thomas J.} and Berean, {Kenneth W.} and Al-Katan, {Hind M.} and Sylvia Pasternak and Giulio Bonavolont{\`a} and Diego Strianese and Peerooz Saeed and Feldman, {Kenneth A.} and Sumalee Vangveeravong and Lapointe, {Jocelyne S.} and White, {Valerie A.}",

year = "2009",

doi = "https://doi.org/10.1001/archophthalmol.2009.209",

language = "English",

volume = "127",

pages = "1016--1028",

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publisher = "American Medical Association",

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T1 - Epithelial lacrimal gland tumors: pathologic classification and current understanding

AU - Weis, Ezekiel

AU - Rootman, Jack

AU - Joly, Thomas J.

AU - Berean, Kenneth W.

AU - Al-Katan, Hind M.

AU - Pasternak, Sylvia

AU - Bonavolontà, Giulio

AU - Strianese, Diego

AU - Saeed, Peerooz

AU - Feldman, Kenneth A.

AU - Vangveeravong, Sumalee

AU - Lapointe, Jocelyne S.

AU - White, Valerie A.

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. METHODS: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. RESULTS: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. CONCLUSIONS: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions

AB - OBJECTIVE: To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. METHODS: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. RESULTS: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. CONCLUSIONS: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions

U2 - https://doi.org/10.1001/archophthalmol.2009.209

DO - https://doi.org/10.1001/archophthalmol.2009.209

M3 - Article

C2 - 19667339

SN - 0003-9950

VL - 127

SP - 1016

EP - 1028

JO - Archives of ophthalmology

JF - Archives of ophthalmology

IS - 8

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