TY - JOUR
T1 - Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth
AU - Peelen, Myrthe J.C.S.
AU - Kazemier, Brenda M.
AU - Ravelli, Anita C.J.
AU - de Groot, Christianne J.M.
AU - van der Post, Joris A.M.
AU - Mol, Ben W.J.
AU - Kok, Marjolein
AU - Hajenius, Petra J.
N1 - Funding Information: Conflict of interest Dr. Mol is supported by a NHMRC Investigator grant (GNT1176437) and reports consultancy for ObsEva, Merck KGaA, iGenomix, and Guerbet. All other authors declare no competing interests. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Objective: To study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities. Study design: National cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared. Result: In each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%). Conclusion: Male fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.
AB - Objective: To study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities. Study design: National cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared. Result: In each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%). Conclusion: Male fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.
UR - http://www.scopus.com/inward/record.url?scp=85102381824&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41372-021-01024-7
DO - https://doi.org/10.1038/s41372-021-01024-7
M3 - Article
C2 - 33750936
SN - 0743-8346
VL - 41
SP - 2165
EP - 2172
JO - Journal of perinatology
JF - Journal of perinatology
IS - 9
ER -