TY - JOUR
T1 - Ethnic disparities in the association between low-grade inflammation biomarkers and chronic kidney disease
T2 - The HELIUS Cohort Study
AU - Mosterd, Charlotte M.
AU - Hayfron-Benjamin, Charles F.
AU - van den Born, Bert-Jan H.
AU - Maitland - van der Zee, Anke H.
AU - Agyemang, Charles
AU - van Raalte, Daniel H.
N1 - Funding Information: We are most thankful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants, and other staff who have taken part in gathering the data in this study. We gratefully acknowledge the AMC Biobank for support in biobank management and storage of collected samples. Publisher Copyright: © 2022 The Authors
PY - 2022/8
Y1 - 2022/8
N2 - Aims: Ethnic differences exist in the prevalence and progression of chronic kidney disease (CKD). However, underlying mechanisms remain unclear. It has been proposed that chronic low-grade inflammation plays an important role in CKD pathogenesis. In the current analysis, we study the association between systemic inflammatory biomarkers and CKD prevalence in different ethnic groups. Methods: We examined cross-sectional associations between biomarkers of low-grade inflammation, including serum high-sensitive (hs)-CRP, fibrinogen, and D-dimer, and CKD prevalence in different ethnic groups residing in Amsterdam, the Netherlands. We included 5740 participants (similar-sized Dutch, African Surinamese, South-Asian Surinamese, Ghanaian, Turkish and Moroccan populations) aged 18 to 70 years of the Healthy Life in an Urban Setting study (HELIUS) cohort. Results: In the fully adjusted models, adjusted for ethnicity-specific cut-off values, elevated fibrinogen [odds ratio 2.50 (95 % confidence interval 1.10–5.78)] and D-dimer [2.99 (1.28–7.00)] were significantly associated with CKD in Dutch. In South-Asian Surinamese, a significant association with elevated D-dimer [2.66 (1.32–5.37)] was found. Conclusions: Our study shows that there are both differences in biomarker levels and the association with CKD across ethnic groups. Future research to identify potential drivers of the differential associations and susceptibility of CKD among ethnic groups to reduce the CKD burden is necessary.
AB - Aims: Ethnic differences exist in the prevalence and progression of chronic kidney disease (CKD). However, underlying mechanisms remain unclear. It has been proposed that chronic low-grade inflammation plays an important role in CKD pathogenesis. In the current analysis, we study the association between systemic inflammatory biomarkers and CKD prevalence in different ethnic groups. Methods: We examined cross-sectional associations between biomarkers of low-grade inflammation, including serum high-sensitive (hs)-CRP, fibrinogen, and D-dimer, and CKD prevalence in different ethnic groups residing in Amsterdam, the Netherlands. We included 5740 participants (similar-sized Dutch, African Surinamese, South-Asian Surinamese, Ghanaian, Turkish and Moroccan populations) aged 18 to 70 years of the Healthy Life in an Urban Setting study (HELIUS) cohort. Results: In the fully adjusted models, adjusted for ethnicity-specific cut-off values, elevated fibrinogen [odds ratio 2.50 (95 % confidence interval 1.10–5.78)] and D-dimer [2.99 (1.28–7.00)] were significantly associated with CKD in Dutch. In South-Asian Surinamese, a significant association with elevated D-dimer [2.66 (1.32–5.37)] was found. Conclusions: Our study shows that there are both differences in biomarker levels and the association with CKD across ethnic groups. Future research to identify potential drivers of the differential associations and susceptibility of CKD among ethnic groups to reduce the CKD burden is necessary.
KW - C-reactive protein
KW - Chronic kidney disease
KW - D-dimer
KW - Ethnicity
KW - Fibrinogen
KW - Inflammatory biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85133704696&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jdiacomp.2022.108238
DO - https://doi.org/10.1016/j.jdiacomp.2022.108238
M3 - Article
C2 - 35791984
SN - 1056-8727
VL - 36
JO - Journal of diabetes and its complications
JF - Journal of diabetes and its complications
IS - 8
M1 - 108238
ER -