TY - JOUR
T1 - European Society for Organ Transplantation (ESOT)-TLJ 3.0 Consensus on Histopathological Analysis of Pre-Implantation Donor Kidney Biopsy
T2 - Redefining the Role in the Process of Graft Assessment
AU - Zaza, Gianluigi
AU - Cucchiari, David
AU - Becker, Jan Ulrich
AU - de Vries, Aiko P. J.
AU - Eccher, Albino
AU - Florquin, Sandrine
AU - Kers, Jesper
AU - Rabant, Marion
AU - Rossini, Michele
AU - Pengel, Liset
AU - Marson, Lorna
AU - on behalf of the ESOT Workgroup on Pre-Implantation Donor Kidney Biopsy and the ESOT Guidelines Taskforce
AU - Furian, Lucrezia
N1 - Funding Information: All costs related to taskforce and workgroup meetings were covered by ESOT, without external funding. JB was supported by the Deutsche Forschungsgemeinschaft (DFG) with grant BE-3801. Funding Information: All costs related to taskforce and workgroup meetings were covered by ESOT, without external funding. JB was supported by the Deutsche Forschungsgemeinschaft (DFG) with grant BE-3801. Publisher Copyright: Copyright © 2023 Zaza, Cucchiari, Becker, de Vries, Eccher, Florquin, Kers, Rabant, Rossini, Pengel, Marson and Furian.
PY - 2023
Y1 - 2023
N2 - The ESOT TLJ 3.0. consensus conference brought together leading experts in transplantation to develop evidence-based guidance on the standardization and clinical utility of pre-implantation kidney biopsy in the assessment of grafts from Expanded Criteria Donors (ECD). Seven themes were selected and underwent in-depth analysis after formulation of PICO (patient/population, intervention, comparison, outcomes) questions. After literature search, the statements for each key question were produced, rated according the GRADE approach [Quality of evidence: High (A), Moderate (B), Low (C); Strength of Recommendation: Strong (1), Weak (2)]. The statements were subsequently presented in-person at the Prague kick-off meeting, discussed and voted. After two rounds of discussion and voting, all 7 statements reached an overall agreement of 100% on the following issues: needle core/wedge/punch technique representatively [B,1], frozen/paraffin embedded section reliability [B,2], experienced/non-experienced on-call renal pathologist reproducibility/accuracy of the histological report [A,1], glomerulosclerosis/other parameters reproducibility [C,2], digital pathology/light microscopy in the measurement of histological variables [A,1], special stainings/Haematoxylin and Eosin alone comparison [A,1], glomerulosclerosis reliability versus other histological parameters to predict the graft survival, graft function, primary non-function [B,1]. This methodology has allowed to reach a full consensus among European experts on important technical topics regarding pre-implantation biopsy in the ECD graft assessment.
AB - The ESOT TLJ 3.0. consensus conference brought together leading experts in transplantation to develop evidence-based guidance on the standardization and clinical utility of pre-implantation kidney biopsy in the assessment of grafts from Expanded Criteria Donors (ECD). Seven themes were selected and underwent in-depth analysis after formulation of PICO (patient/population, intervention, comparison, outcomes) questions. After literature search, the statements for each key question were produced, rated according the GRADE approach [Quality of evidence: High (A), Moderate (B), Low (C); Strength of Recommendation: Strong (1), Weak (2)]. The statements were subsequently presented in-person at the Prague kick-off meeting, discussed and voted. After two rounds of discussion and voting, all 7 statements reached an overall agreement of 100% on the following issues: needle core/wedge/punch technique representatively [B,1], frozen/paraffin embedded section reliability [B,2], experienced/non-experienced on-call renal pathologist reproducibility/accuracy of the histological report [A,1], glomerulosclerosis/other parameters reproducibility [C,2], digital pathology/light microscopy in the measurement of histological variables [A,1], special stainings/Haematoxylin and Eosin alone comparison [A,1], glomerulosclerosis reliability versus other histological parameters to predict the graft survival, graft function, primary non-function [B,1]. This methodology has allowed to reach a full consensus among European experts on important technical topics regarding pre-implantation biopsy in the ECD graft assessment.
KW - consensus paper
KW - expanded criteria donors
KW - histopathology
KW - kidney transplantation
KW - pre-implantation kidney biopsy
UR - http://www.scopus.com/inward/record.url?scp=85165151620&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/ti.2023.11410
DO - https://doi.org/10.3389/ti.2023.11410
M3 - Article
C2 - 37470063
SN - 0934-0874
VL - 36
JO - Transplant international
JF - Transplant international
M1 - 11410
ER -