TY - JOUR
T1 - European Surveillance System on Contact Allergies (ESSCA)
T2 - polysensitization, 2009–2014
AU - for the ESSCA Network
AU - Dittmar, Daan
AU - Uter, Wolfgang
AU - Bauer, Andrea
AU - Fortina, Ana B.
AU - Bircher, Andreas J.
AU - Czarnecka-Operacz, Magdalena
AU - Dugonik, Aleksandra
AU - Elsner, Peter
AU - Gallo, Rosella
AU - Ghaffar, Sharizan A.
AU - Giménez-Arnau, Anna
AU - Johnston, Graham A.
AU - Kręcisz, Beata
AU - Filon, Francesca L.
AU - Rustemeyer, Thomas
AU - Sadowska-Przytocka, Anna
AU - Sánchez-Pérez, Javier
AU - Schnuch, Axel
AU - Simon, Dagmar
AU - Spiewak, Radoslaw
AU - Spring, Philipp
AU - Corradin, Maria T.
AU - Valiukevičienė, Skaidra
AU - Vok, Marko
AU - Weisshaar, Elke
AU - Wilkinson, Mark
AU - Schuttelaar, Marie L.
AU - Aberer, Werner
AU - Ballmer-Weber, Barbara
AU - Grabbe, Jürgen
AU - Beiteke, Ulrike
AU - Brasch, Jochen
AU - Fuchs, Thomas
AU - John, Swen Malte
AU - Mahler, Vera
AU - Pesonen, Maria
AU - Jolanki, Riitta
AU - Rantanen, Tapio
AU - Armario-Hita, José Carlos
AU - Fernández-Redondo, Virginia
AU - García-Gavín, Juan
AU - Mercader, Pedro
AU - Ruiz, Inmaculada
AU - Silvestre, Juan Fco
AU - Balato, Anna
AU - Ayala, Fabio
AU - Peserico, Andrea
AU - Sliuziaviciene, Gondinga
AU - Kieć-Świerczyńska, Marta
AU - Kmecl, Tanja
AU - ESSCA Network
N1 - Funding Information: The present study was not sponsored; the ESSCA had received initial start-up funding from the EU (QLK4-CT-2001-00343 and QLK4-CT-2001-2812) in 2002–2004. Publisher Copyright: © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life. Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization. Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed. Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization. Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.
AB - Background: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life. Objectives: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization. Methods: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) in consecutively patch tested patients from January 2009 to December 2014, comprising 11 countries and 57 departments, were retrospectively analysed. Results: A total of 86 416 patients were available for analysis, showing a standardized prevalence of polysensitization of 7.02%, ranging from 12.7% (Austria) to 4.6% (Italy). Allergen pairs with the strongest association are reported for the total population, for South Europe, and for North/Central Europe. Overall, polysensitized patients showed a higher percentage of extreme (+++) positive patch test reactions than oligosensitized patients. Female sex, occupational dermatitis and age > 40 years were risk factors for polysensitization. Conclusions: The varying prevalences of polysensitization across Europe most likely reflect differences in patient characteristics and referral patterns between departments. Known risk factors for polysensitization are confirmed in a European dermatitis population.
KW - clinical epidemiology
KW - contact allergy
KW - patch test
KW - polysensitization
UR - http://www.scopus.com/inward/record.url?scp=85046374512&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046374512&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29468728
U2 - https://doi.org/10.1111/cod.12966
DO - https://doi.org/10.1111/cod.12966
M3 - Article
C2 - 29468728
SN - 0105-1873
VL - 78
SP - 373
EP - 385
JO - Contact dermatitis
JF - Contact dermatitis
IS - 6
ER -