TY - JOUR
T1 - Evaluation of appendicular lean mass using bio impedance in persons aged 80+: A new equation based on the BUTTERFLY-study
AU - Vermeiren, S.
AU - Beckwée, D.
AU - Vella-Azzopardi, R.
AU - Beyer, I.
AU - Knoop, V.
AU - Jansen, B.
AU - Delaere, A.
AU - Antoine, A.
AU - Bautmans, I.
AU - Scafoglieri, A.
AU - Bautmans, Ivan
AU - Verté, Dominque
AU - Beyer, Ingo
AU - Petrovic, Mirko
AU - de Donder, Liesbeth
AU - Kardol, Tinie
AU - Rossi, Gina
AU - Clarys, Peter
AU - Scafoglieri, Aldo
AU - Cattrysse, Erik
AU - de Hert, Paul
AU - Jansen, Bart
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background: To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear. Objective: We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia. Design: 174 community dwelling well-functioning persons (83 women, 91 men) aged 80 and over were included. Appendicular lean mass (ALM) was predicted using BIA-based equations available in literature, and compared to DXA outcomes. Through cross-validation and stepwise multiple linear regression, a new ALM-formula was generated suitable for this population. Results: Literature-based BIA equations systematically overestimated ALM. The new prediction formula that we propose for the 80+ is: ALM = 0,827+(0,19*Impedance Index)+(2,101*Sex)+(0,079*Weight); R2 = 0,888; SEE = 1,450 kg. Sarcopenia classification based on our new BIA equation for ALM showed better agreement with DXA (k ≥ 0,454) compared to literature-based BIA equations (k < 0,368). Conclusions: Despite the high correlation between both methods, literature-based BIA equations consistently overestimate ALM compared to DXA in persons aged 80 and over. We proposed a new equation for ALM, reaching higher agreement with DXA and thus improving the accuracy of BIA for this specific age group.
AB - Background: To date, the accuracy of bio-impedance (BIA) to assess body composition & sarcopenia in persons aged 80 and over remains unclear. Objective: We aimed to evaluate the agreement between dual energy X-ray absorptiometry (DXA) and BIA equations to determine lean mass, as well as their suitability to identify sarcopenia. Design: 174 community dwelling well-functioning persons (83 women, 91 men) aged 80 and over were included. Appendicular lean mass (ALM) was predicted using BIA-based equations available in literature, and compared to DXA outcomes. Through cross-validation and stepwise multiple linear regression, a new ALM-formula was generated suitable for this population. Results: Literature-based BIA equations systematically overestimated ALM. The new prediction formula that we propose for the 80+ is: ALM = 0,827+(0,19*Impedance Index)+(2,101*Sex)+(0,079*Weight); R2 = 0,888; SEE = 1,450 kg. Sarcopenia classification based on our new BIA equation for ALM showed better agreement with DXA (k ≥ 0,454) compared to literature-based BIA equations (k < 0,368). Conclusions: Despite the high correlation between both methods, literature-based BIA equations consistently overestimate ALM compared to DXA in persons aged 80 and over. We proposed a new equation for ALM, reaching higher agreement with DXA and thus improving the accuracy of BIA for this specific age group.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051507050&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30119982
U2 - https://doi.org/10.1016/j.clnu.2018.07.029
DO - https://doi.org/10.1016/j.clnu.2018.07.029
M3 - Article
C2 - 30119982
SN - 0261-5614
VL - 38
SP - 1756
EP - 1764
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 4
ER -