TY - JOUR
T1 - Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update
T2 - results of a systematic literature search update
AU - Stoffer, Michaela A.
AU - Schoels, Monika M.
AU - Smolen, Josef S.
AU - Aletaha, Daniel
AU - Breedveld, Ferdinand C.
AU - Burmester, Gerd
AU - Bykerk, Vivian
AU - Dougados, Maxime
AU - Emery, Paul
AU - Haraoui, Boulos
AU - Gomez-Reino, Juan
AU - Kvien, Tore K.
AU - Nash, Peter
AU - Navarro-Compán, Victoria
AU - Scholte-Voshaar, Marieke
AU - van Vollenhoven, Ronald
AU - van der Heijde, Désirée
AU - Stamm, Tanja A.
PY - 2016/1
Y1 - 2016/1
N2 - A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations. Two SLRs focused on clinical trials employing a treatment approach targeting a specific clinical outcome were performed. In addition to testing clinical, functional and/or structural changes as endpoints, comorbidities, cardiovascular risk, work productivity and education as well as patient self-assessment were investigated. The searches covered MEDLINE, EMBASE, Cochrane databases and Clinicaltrial.gov for the period between 2009 and 2012 and separately for the period of 2012 to May of 2014. Of 8442 citations retrieved in the two SLRs, 176 articles underwent full-text review. According to predefined inclusion/exclusion criteria, six articles were included of which five showed superiority of a targeted treatment approach aiming at least at low-disease activity versus routine care; in addition, publications providing supportive evidence were also incorporated that aside from expanding the evidence provided by the above six publications allowed concluding that a target-oriented approach leads to less comorbidities and cardiovascular risk and better work productivity than conventional care. The current study expands the evidence that targeting low-disease activity or remission in the management of RA conveys better outcomes than routine care
AB - A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations. Two SLRs focused on clinical trials employing a treatment approach targeting a specific clinical outcome were performed. In addition to testing clinical, functional and/or structural changes as endpoints, comorbidities, cardiovascular risk, work productivity and education as well as patient self-assessment were investigated. The searches covered MEDLINE, EMBASE, Cochrane databases and Clinicaltrial.gov for the period between 2009 and 2012 and separately for the period of 2012 to May of 2014. Of 8442 citations retrieved in the two SLRs, 176 articles underwent full-text review. According to predefined inclusion/exclusion criteria, six articles were included of which five showed superiority of a targeted treatment approach aiming at least at low-disease activity versus routine care; in addition, publications providing supportive evidence were also incorporated that aside from expanding the evidence provided by the above six publications allowed concluding that a target-oriented approach leads to less comorbidities and cardiovascular risk and better work productivity than conventional care. The current study expands the evidence that targeting low-disease activity or remission in the management of RA conveys better outcomes than routine care
KW - Antirheumatic Agents
KW - Arthritis, Rheumatoid
KW - Clinical Trials as Topic
KW - Comorbidity
KW - Evidence-Based Medicine
KW - Humans
KW - Journal Article
KW - Patient Care Planning
KW - Radiography
KW - Research Support, Non-U.S. Gov't
KW - Review
KW - Severity of Illness Index
KW - Treatment Outcome
U2 - https://doi.org/10.1136/annrheumdis-2015-207526
DO - https://doi.org/10.1136/annrheumdis-2015-207526
M3 - Review article
C2 - 25990290
SN - 0003-4967
VL - 75
SP - 16
EP - 22
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 1
ER -