TY - JOUR
T1 - Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls
T2 - Results from the EUGEI study
AU - Genetic Risk and OUtcome of Psychosis (GROUP) Investigators
AU - Fusar-Poli, Laura
AU - Prachason, Thanavadee
AU - Erzin, Gamze
AU - Pries, Lotta Katrin
AU - Brondino, Natascia
AU - Politi, Pierluigi
AU - Delespaul, Philippe
AU - Kenis, Gunter
AU - Luykx, Jurjen J.
AU - Lin, Bochao D.
AU - Richards, Alexander L.
AU - Akdede, Berna
AU - Binbay, Tolga
AU - Altınyazar, Vesile
AU - Yalınçetin, Berna
AU - Gümüş-Akay, Güvem
AU - Cihan, Burçin
AU - Soygür, Haldun
AU - Ulaş, Halis
AU - Cankurtaran, Eylem Şahin
AU - Kaymak, Semra Ulusoy
AU - Mihaljevic, Marina M.
AU - Andric-Petrovic, Sanja
AU - Mirjanic, Tijana
AU - Bernardo, Miguel
AU - Mezquida, Gisela
AU - Amoretti, Silvia
AU - Bobes, Julio
AU - Saiz, Pilar A.
AU - García-Portilla, Maria Paz
AU - Sanjuan, Julio
AU - Escarti, Maria Jose
AU - Santos, José Luis
AU - Jiménez-López, Estela
AU - Arrojo, Manuel
AU - Carracedo, Angel
AU - López, Gonzalo
AU - González-Peñas, Javier
AU - Parellada, Mara
AU - Maric, Nadja P.
AU - Atbaşoğlu, Cem
AU - Üçok, Alp
AU - Alptekin, Köksal
AU - Saka, Meram Can
AU - Arango, Celso
AU - O'Donovan, Michael
AU - van Os, Jim
AU - Rutten, Bart PF
AU - Guloksuz, Sinan
N1 - Publisher Copyright: © 2023
PY - 2023/5
Y1 - 2023/5
N2 - Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group. Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI -0.76 to -0.03) and healthy controls (B=-0.63, 95% CI -1.06 to -0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings. Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.
AB - Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group. Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI -0.76 to -0.03) and healthy controls (B=-0.63, 95% CI -1.06 to -0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings. Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.
KW - Cannabis use
KW - Childhood trauma
KW - Emotion recognition
KW - Environment
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85151411106&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2023.115184
DO - 10.1016/j.psychres.2023.115184
M3 - Article
C2 - 37015164
SN - 0165-1781
VL - 323
JO - Psychiatry Research
JF - Psychiatry Research
M1 - 115184
ER -