TY - JOUR
T1 - Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative
AU - TOPICS-MDS research consortium, Steering Committee, Working group
AU - Hofman, Cynthia S.
AU - Lutomski, Jennifer E.
AU - Boter, Han
AU - Buurman, Bianca M.
AU - De Craen, Anton J.M.
AU - Donders, Rogier
AU - Rikkert, Marcel G.M.Olde
AU - Makai, Peter
AU - Melis, René J.F.
AU - Bleijenberg, N.
AU - Blom, J. W.
AU - Kempen, G. I.J.M.
AU - Krabbe, P. F.M.
AU - Moll Van Charante, E. P.
AU - Muntinga, M.
AU - Steyerberg, E. W.
AU - Gussekloo, J.
AU - Van Der Horst, H. E.
AU - Olde Rikkert, M. G.M.
AU - De Rooij, S. E.J.A.
AU - Schols, J. M.G.A.
AU - Schuurmans, M. J.
AU - Smilde, D. A.
AU - Van Den Brink, D.
AU - Qin, L.
AU - TOPICS-MDS research consortium
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital). Methods Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril's ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression. Results In the complete sample and when stratified by study setting TOPICS-CEP and Cantril's ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup. Conclusion This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.
AB - Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital). Methods Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril's ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression. Results In the complete sample and when stratified by study setting TOPICS-CEP and Cantril's ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup. Conclusion This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.
UR - http://www.scopus.com/inward/record.url?scp=85015422629&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0173081
DO - 10.1371/journal.pone.0173081
M3 - Article
C2 - 28296910
SN - 1932-6203
VL - 12
SP - e0173081
JO - PLOS ONE
JF - PLOS ONE
IS - 3
M1 - e0173081
ER -