Exceptional response of brain metastases to short course nivolumab while on high-dose steroids

W. K. De Jong, A. C.M. Mulders, W. Westendorp, A. Becker

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)


In this manuscript, we describe a patient with an exceptional response of brain metastases from lung cancer to short course nivolumab while on high-dose steroids. This case shows that immunotherapy can cause delayed and enduring responses even in patients with poor predictive parameters for treatment success, such as low programmed death ligand-1 (PDL1) expression and long-term treatment with high-dose corticosteroids. Secondly, it underscores the importance of follow up after the administration of immunotherapy, even in cases with a deemed poor prognosis and few received cycles of immunotherapy.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalNetherlands journal of medicine
Issue number9
Publication statusPublished - Nov 2019


  • Brain metastases
  • Immunotherapy
  • Poor predictive factors

Cite this