TY - JOUR
T1 - Executive functioning of patients with congenital heart disease
T2 - 45 years after surgery
AU - Pelosi, C.
AU - Kauling, R.M.
AU - Cuypers, J.A.A.E.
AU - Utens, E.M.W.J.
AU - van den Bosch, A.E.
AU - Kardys, I.
AU - Bogers, A.J.J.C.
AU - Helbing, W.A.
AU - Roos-Hesselink, J.W.
AU - Legerstee, J.S.
N1 - With supplementary file.
PY - 2023/10
Y1 - 2023/10
N2 - BACKGROUND: Nowadays, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, long-term impact on neurodevelopment and executive functioning in adults with CHD are not completely understood.PURPOSE: To investigate the self- and informant-reported executive functioning in adults with CHD operated in childhood.MATERIAL AND METHODS: Longitudinal study of a cohort of patients (n = 194, median age: 49.9 [46.1-53.8]) who were operated in childhood (< 15 years old) between 1968 and 1980 (median follow-up time: 45 [40-53] years) for one of the following diagnoses: atrial septal defect (ASD), ventricular septal defect (VSD), pulmonary stenosis (PS), tetralogy of Fallot (ToF) or transposition of the great arteries (TGA). Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A) questionnaire was used to assess self- and informant-reported executive functioning.RESULTS: 40-53 years after surgery, the CHD group did show significantly better executive functioning compared to the norm data. No significant difference was found between mild CHD (ASD, VSD and PS) and moderate/severe CHD (ToF and TGA). Higher education, NYHA class 1 and better exercise capacity were associated with better self-reported executive functioning, whereas females or patients taking psychiatric or cardiac medications reported worse executive functioning.CONCLUSIONS: Our findings suggest favorable outcomes (comparable to normative data) regarding executive functioning in adults with CHD, both self- and informant-reported. However, further study is warranted to explore more in detail the different cognitive domains of executive functioning in these patients.
AB - BACKGROUND: Nowadays, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, long-term impact on neurodevelopment and executive functioning in adults with CHD are not completely understood.PURPOSE: To investigate the self- and informant-reported executive functioning in adults with CHD operated in childhood.MATERIAL AND METHODS: Longitudinal study of a cohort of patients (n = 194, median age: 49.9 [46.1-53.8]) who were operated in childhood (< 15 years old) between 1968 and 1980 (median follow-up time: 45 [40-53] years) for one of the following diagnoses: atrial septal defect (ASD), ventricular septal defect (VSD), pulmonary stenosis (PS), tetralogy of Fallot (ToF) or transposition of the great arteries (TGA). Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A) questionnaire was used to assess self- and informant-reported executive functioning.RESULTS: 40-53 years after surgery, the CHD group did show significantly better executive functioning compared to the norm data. No significant difference was found between mild CHD (ASD, VSD and PS) and moderate/severe CHD (ToF and TGA). Higher education, NYHA class 1 and better exercise capacity were associated with better self-reported executive functioning, whereas females or patients taking psychiatric or cardiac medications reported worse executive functioning.CONCLUSIONS: Our findings suggest favorable outcomes (comparable to normative data) regarding executive functioning in adults with CHD, both self- and informant-reported. However, further study is warranted to explore more in detail the different cognitive domains of executive functioning in these patients.
KW - Adult
KW - Congenital heart disease
KW - Executive Function
KW - Female
KW - Heart Defects, Congenital/complications
KW - Heart Septal Defects, Atrial/complications
KW - Heart Septal Defects, Ventricular/complications
KW - Humans
KW - Long-term follow-up
KW - Longitudinal Studies
KW - Middle Aged
KW - Psychology
KW - Transposition of Great Vessels/complications
UR - https://pure.uva.nl/ws/files/148225559/392_2023_2187_MOESM1_ESM.docx
UR - http://www.scopus.com/inward/record.url?scp=85152130990&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00392-023-02187-3
DO - https://doi.org/10.1007/s00392-023-02187-3
M3 - Article
C2 - 37031447
SN - 1861-0684
VL - 112
SP - 1417
EP - 1426
JO - Clinical research in cardiology
JF - Clinical research in cardiology
IS - 10
ER -