TY - JOUR
T1 - Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises
AU - Boots, Agnes W.
AU - Bos, Lieuwe D.
AU - van der Schee, Marc P.
AU - van Schooten, Frederik-Jan
AU - Sterk, Peter J.
PY - 2015
Y1 - 2015
N2 - Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies
AB - Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies
U2 - https://doi.org/10.1016/j.molmed.2015.08.001
DO - https://doi.org/10.1016/j.molmed.2015.08.001
M3 - Review article
C2 - 26432020
SN - 1471-4914
VL - 21
SP - 633
EP - 644
JO - Trends in molecular medicine
JF - Trends in molecular medicine
IS - 10
ER -