TY - JOUR
T1 - Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study
AU - Vijverberg, Susanne J. H.
AU - Koster, Ellen S.
AU - Koenderman, Leo
AU - Arets, Hubertus G. M.
AU - van der Ent, Cornelis K.
AU - Postma, Dirkje S.
AU - Koppelman, Gerard H.
AU - Raaijmakers, Jan A. M.
AU - Maitland-van der Zee, Anke-Hilse
PY - 2012
Y1 - 2012
N2 - To cite this article: Vijverberg SJH, Koster ES, Koenderman L, Arets HGM, van der Ent CK, Postma DS, Koppelman GH, Raaijmakers JAM, Maitland-van der Zee A-H. Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study. Pediatr Allergy Immunol 2012: 23: 529536. Abstract Background: A high fraction of nitric oxide in exhaled breath (FeNO) has been suggested to be a marker of ongoing airway inflammation and poorly controlled disease in asthma. The usefulness of FeNO to monitor asthma control is still debated today. Aim: To assess the validity of FeNO as a marker of asthma control in children with reported use of asthma medication. Methods: Fraction of nitric oxide in exhaled breath was measured in 601 children (aged 412 yr) with reported use of asthma medication in the past 6 months and in 63 healthy non-asthmatic children (aged 512). Asthma control was assessed by the Asthma Control Questionnaire (ACQ). A receiver-operator characteristics (ROC) curve was generated to assess the accuracy of FeNO as a marker for asthma control. Logistic regression analysis was used to study whether clinical, healthcare, medication, and environmental factors are associated with high FeNO levels (>25 ppb). Results: Fraction of nitric oxide in exhaled breath had a poor accuracy to discriminate well-controlled from not well-controlled asthma [area under the ROC curve: 0.56 (95% CI: 0.520.61, p = 0.008)]. In addition, high FeNO (>25 ppb) was associated with lower medication adherence rates (OR: 0.4; 95% CI 0.30.6), fewer antibiotic courses in the past year (OR: 0.6; 95% CI: 0.40.9), fewer leukotriene antagonists use in the past year (OR: 0.4; 95% CI: 0.20.9), and fewer visits to a (pulmonary) pediatrician (OR: 0.6; 95% CI: 0.40.9). Children living in a non-urban environment had more often high FeNO levels (OR: 1.7; 95% CI: 1.12.6). Conclusion: High FeNO is a poor marker of asthma control in children with reported use of asthma medication. Various other factors, including medication adherence and medication use, are associated with increased FeNO levels
AB - To cite this article: Vijverberg SJH, Koster ES, Koenderman L, Arets HGM, van der Ent CK, Postma DS, Koppelman GH, Raaijmakers JAM, Maitland-van der Zee A-H. Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study. Pediatr Allergy Immunol 2012: 23: 529536. Abstract Background: A high fraction of nitric oxide in exhaled breath (FeNO) has been suggested to be a marker of ongoing airway inflammation and poorly controlled disease in asthma. The usefulness of FeNO to monitor asthma control is still debated today. Aim: To assess the validity of FeNO as a marker of asthma control in children with reported use of asthma medication. Methods: Fraction of nitric oxide in exhaled breath was measured in 601 children (aged 412 yr) with reported use of asthma medication in the past 6 months and in 63 healthy non-asthmatic children (aged 512). Asthma control was assessed by the Asthma Control Questionnaire (ACQ). A receiver-operator characteristics (ROC) curve was generated to assess the accuracy of FeNO as a marker for asthma control. Logistic regression analysis was used to study whether clinical, healthcare, medication, and environmental factors are associated with high FeNO levels (>25 ppb). Results: Fraction of nitric oxide in exhaled breath had a poor accuracy to discriminate well-controlled from not well-controlled asthma [area under the ROC curve: 0.56 (95% CI: 0.520.61, p = 0.008)]. In addition, high FeNO (>25 ppb) was associated with lower medication adherence rates (OR: 0.4; 95% CI 0.30.6), fewer antibiotic courses in the past year (OR: 0.6; 95% CI: 0.40.9), fewer leukotriene antagonists use in the past year (OR: 0.4; 95% CI: 0.20.9), and fewer visits to a (pulmonary) pediatrician (OR: 0.6; 95% CI: 0.40.9). Children living in a non-urban environment had more often high FeNO levels (OR: 1.7; 95% CI: 1.12.6). Conclusion: High FeNO is a poor marker of asthma control in children with reported use of asthma medication. Various other factors, including medication adherence and medication use, are associated with increased FeNO levels
U2 - https://doi.org/10.1111/j.1399-3038.2012.01279.x
DO - https://doi.org/10.1111/j.1399-3038.2012.01279.x
M3 - Article
C2 - 22624949
SN - 0905-6157
VL - 23
SP - 529-+
JO - Pediatric allergy and immunology
JF - Pediatric allergy and immunology
IS - 6
ER -