Experimentally-induced autonomic neuropathy: beneficial effect of a topical ACTH4-9 analogue on oculomotor nerve regeneration: Beneficial effect of a topical acth4–9 analogue on oculomotor nerve regeneration

W. P. Vandertop, W. B. de Vries, N. C. Notermans, C. A. Tulleken, W. H. Gispen

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


Melanocortins, peptides related to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH4-9 analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH4-9 analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery
Original languageEnglish
Pages (from-to)457-61; discussion 462
Number of pages6
Issue number3
Publication statusPublished - 1 Jan 1994


  • Acth analogue
  • Autonomic neuropathy
  • Melanocortins
  • Nerve regeneration
  • Neuropeptides

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