Exploración de la red cerebral: una revisión de la conectividad funcional en la RMf en estado de reposo

Translated title of the contribution: Exploring the brain network: A review on resting-state fMRI functional connectivity

Martijn P. Van Den Heuvel, Hilleke E.Hulshoff Pol

Research output: Contribution to journalShort surveyAcademicpeer-review

15 Citations (Scopus)


Our brain is a network. It consists of spatially distributed, but functionally linked regions that continuously share information with each other. Interestingly, recent advances in the acquisitionand analysis of functional neuroimaging data have catalyzed the exploration of functional connectivity in the human brain. Functional connectivity is defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions and in the past years an increasing body of neuroimaging studies has started to explore functional connectivity by measuring the level of co-activation of resting-state fMRI time-series between brain regions. These studies have revealed interesting new findings about the functional connections of specific brain regions and local networks, as well as important new insights in the overall organization of functional communication in the brain network. Here we present an overview of these new methods and discuss how they have led to new insights in core aspects of the human brain, providing an overview of these novel imaging techniques and their implication to neuroscience. We discuss the use of spontaneous resting-state fMRI in determining functional connectivity, discuss suggested origins of these signals, how functional connections tend to be related to structural connections in the brain network and how functional brain communication may form a key role in cognitive performance. Furthermore, we will discuss the upcoming field of examining functional connectivity patterns using graph theory, focusing on the overall organization of the functional brain network. Specifically, we will discuss the value of these new functional connectivity tools in examining believed connectivity diseases, like Alzheimer's disease, dementia, schizophrenia and multiple sclerosis.

Translated title of the contributionExploring the brain network: A review on resting-state fMRI functional connectivity
Original languageSpanish
Pages (from-to)28-41
Number of pages14
JournalPsiquiatria Biologica
Issue number1
Publication statusPublished - 1 Jan 2011


  • Anatomical connectivity
  • Complex systems
  • Complexity
  • Diffusion tensor imaging
  • Diffusion tensor imaging (DTI)
  • Functional brain networks
  • Functional connectivity
  • Functional magnetic resonance imaging (fMRI)
  • Graph analysis
  • Network
  • Network analysis
  • Resting-state connectivity
  • Resting-state fMRI
  • Review
  • White matter

Cite this