Exposure to occupational antigens might predispose to IgG4-related disease

Lucas J.Maillette de Buy Wenniger; Emma L. Culver; Ulrich Beuers

doi:https://doi.org/10.1002/hep.26999

Exposure to occupational antigens might predispose to IgG4-related disease

Lucas J.Maillette de Buy Wenniger, Emma L. Culver, Ulrich Beuers

Research output: Contribution to journal › Letter › Academic › peer-review

98 Citations (Scopus)

Abstract

Evidence is mounting that the immune system of patients with IgG4-related disease (IgG4-RD) shows indications of chronic antigenic stimulation. Hypothesizing a possible role for occupational antigenic exposure, we observed in two independent cohorts of patients with IgG4-RD that the majority had had a career in blue collar occupations with prolonged exposures to potentially hazardous occupational antigens. We postulate that the chronic antigenic load associated with 'dirty' jobs could be one of the factors contributing to the development of IgG4-related disease. (Hepatology 2014;)

Original language	English
Pages (from-to)	1453-1454
Number of pages	2
Journal	Hepatology
Volume	60
Issue number	4
DOIs	https://doi.org/10.1002/hep.26999
Publication status	Published - 1 Oct 2014

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AU - Beuers, Ulrich

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N2 - Evidence is mounting that the immune system of patients with IgG4-related disease (IgG4-RD) shows indications of chronic antigenic stimulation. Hypothesizing a possible role for occupational antigenic exposure, we observed in two independent cohorts of patients with IgG4-RD that the majority had had a career in blue collar occupations with prolonged exposures to potentially hazardous occupational antigens. We postulate that the chronic antigenic load associated with 'dirty' jobs could be one of the factors contributing to the development of IgG4-related disease. (Hepatology 2014;)

AB - Evidence is mounting that the immune system of patients with IgG4-related disease (IgG4-RD) shows indications of chronic antigenic stimulation. Hypothesizing a possible role for occupational antigenic exposure, we observed in two independent cohorts of patients with IgG4-RD that the majority had had a career in blue collar occupations with prolonged exposures to potentially hazardous occupational antigens. We postulate that the chronic antigenic load associated with 'dirty' jobs could be one of the factors contributing to the development of IgG4-related disease. (Hepatology 2014;)

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SP - 1453

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JO - Hepatology

JF - Hepatology

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ER -

Exposure to occupational antigens might predispose to IgG4-related disease

Abstract

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