TY - JOUR
T1 - Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease
AU - Houweling, Arjan C.
AU - van Borren, Marcel M.
AU - Moorman, Antoon F. M.
AU - Christoffels, Vincent M.
N1 - Funding Information: This study was supported by The Netherlands Heart Foundation grant NHS M96.002. The authors thank Piet de Boer for his expert technical assistance.
PY - 2005/9/1
Y1 - 2005/9/1
N2 - The endocrine function of the heart was shown by the identification of a potent inhibitor of renal tubular NaCl reabsorbtion, atrial natriuretic peptide/factor (ANP), in atrial extracts. Since then, Nppa, the gene encoding ANP, has become an important tool for molecular and developmental biologists. Expression of Nppa is an early and specific marker for the differentiating working myocardium of the atria and ventricles of the developing heart. Around the time of birth, ventricular Nppa expression is down-regulated, to be reactivated in response to a variety of cardiovascular disorders. Many aspects of the regulatory pathways that control Nppa gene expression during cardiac development or disease have been revealed. However, several fundamental issues remain to be resolved. Particularly, the regulatory mechanisms underlying the ventricular Nppa expression in the embryonic heart and the reactivation in the failing ventricle remain unclear. Here we review current knowledge on the transcriptional regulation of the Nppa gene
AB - The endocrine function of the heart was shown by the identification of a potent inhibitor of renal tubular NaCl reabsorbtion, atrial natriuretic peptide/factor (ANP), in atrial extracts. Since then, Nppa, the gene encoding ANP, has become an important tool for molecular and developmental biologists. Expression of Nppa is an early and specific marker for the differentiating working myocardium of the atria and ventricles of the developing heart. Around the time of birth, ventricular Nppa expression is down-regulated, to be reactivated in response to a variety of cardiovascular disorders. Many aspects of the regulatory pathways that control Nppa gene expression during cardiac development or disease have been revealed. However, several fundamental issues remain to be resolved. Particularly, the regulatory mechanisms underlying the ventricular Nppa expression in the embryonic heart and the reactivation in the failing ventricle remain unclear. Here we review current knowledge on the transcriptional regulation of the Nppa gene
KW - ANF
KW - Gene expression
KW - Heart development
KW - Heart disease
KW - Nppa
KW - Transcriptional regulation
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=22744442083&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cardiores.2005.06.013
DO - https://doi.org/10.1016/j.cardiores.2005.06.013
M3 - Review article
C2 - 16002056
SN - 0008-6363
VL - 67
SP - 583
EP - 593
JO - Cardiovascular research
JF - Cardiovascular research
IS - 4
ER -