Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

V. J. Wielenga; K. H. Heider; G. J. Offerhaus; G. R. Adolf; F. M. van den Berg; H. Ponta; P. Herrlich; S. T. Pals

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

V. J. Wielenga, K. H. Heider, G. J. Offerhaus, G. R. Adolf, F. M. van den Berg, H. Ponta, P. Herrlich, S. T. Pals

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

565 Citations (Scopus)

Abstract

Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases

Original language	English
Pages (from-to)	4754-4756
Journal	Cancer research
Volume	53
Issue number	20
Publication status	Published - 1993

Cite this

@article{8546243f5a91430d8757fffaf658c768,

title = "Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression",

abstract = "Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases",

author = "Wielenga, {V. J.} and Heider, {K. H.} and Offerhaus, {G. J.} and Adolf, {G. R.} and {van den Berg}, {F. M.} and H. Ponta and P. Herrlich and Pals, {S. T.}",

year = "1993",

language = "English",

volume = "53",

pages = "4754--4756",

journal = "Cancer research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "20",

}

TY - JOUR

T1 - Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

AU - Wielenga, V. J.

AU - Heider, K. H.

AU - Offerhaus, G. J.

AU - Adolf, G. R.

AU - van den Berg, F. M.

AU - Ponta, H.

AU - Herrlich, P.

AU - Pals, S. T.

PY - 1993

Y1 - 1993

N2 - Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases

AB - Specific CD44 variant glycoproteins are overexpressed at particular stages of colorectal tumor progression. Some variants of the CD44 glycoprotein without exon v6 sequences appear at the earliest stage of tumorigenesis, i.e., in early adenomas. Expression of variants containing exon v6 sequences is largely restricted to the advanced stages of tumor development and in addition is more prevalent and intense in metastatic (Dukes C/D) than in nonmetastatic (Dukes A/B) carcinomas. The observation that CD44 variants containing a protein domain of CD44 that confers full metastatic potential to rat carcinoma and sarcoma cell lines is increasingly expressed during colorectal tumor progression indicates that this domain may have an important role in tumor progression and metastasis in humans. Information on v6 expression, which can be obtained by routine immunohistochemistry, may prove of important prognostic value, particularly in carcinomas (Dukes A and B) that have not yet given rise to detectable metastases

M3 - Comment/Letter to the editor

C2 - 7691404

SN - 0008-5472

VL - 53

SP - 4754

EP - 4756

JO - Cancer research

JF - Cancer research

IS - 20

ER -