Using degenerated PCR-primers to identify known and novel BMPs that are expressed in the developing chicken heart, we identified not only BMP2, -4, and -7 mRNA, but also the TGFbeta superfamily member cVg1. The expression pattern of cVg1 mRNA was determined during chicken development from HH4 to HH44. In early developmental stages, cVg1 mRNA is expressed in the primitive streak, paraxial mesoderm, developing somites, and developing neural tube. Subsequently, cVg1 mRNA is expressed in the developing central and peripheral nervous system, retina, auditory vesicle, notochord, lung alveoli, and olfactory mucosa. In the heart, cVg1 is initially expressed through the linear heart tube, but becomes restricted to the forming chamber myocardium, in an expression domain similar to that of atrial natriuretic factor (ANF) mRNA
Original languageEnglish
Pages (from-to)603-608
Number of pages6
JournalAnatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
Issue number1
Publication statusPublished - Jul 2003


  • Atrial natriuretic factor
  • Heart
  • Nervous system
  • Otic vesicle
  • Retina
  • TGFβ-superfamily
  • cVg1

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