TY - JOUR
T1 - Expression of ERCC1, p53, and Class III beta-Tubulin Do Not Reveal Chemoresistance in Endometrial Cancer Results From an Immunohistochemical Study
AU - Vandenput, Ingrid
AU - Capoen, An
AU - Coenegrachts, Lieve
AU - Verbist, Godelieve
AU - Moerman, Philippe
AU - Vergote, Ignace
AU - Amant, Frédéric
PY - 2011
Y1 - 2011
N2 - Background: In non-small cell lung cancer, expression of excision repair cross-complementation group 1 (ERCC1) and p53 correlates with platinum resistance and class III beta-tubulin with resistance to taxanes. The potential to personalize treatment in endometrial cancer remains uninvestigated. Methods: Patients received platinum-based chemotherapy, with or without paclitaxel. Patients were divided into 2 groups: group A (n = 33) consisted of patients with early-stage endometrial cancer treated with adjuvant chemotherapy. Group B (n = 116) included cases with primary advanced or recurrent disease. Immunohistochemistry was performed to analyze the expression of ERCC1 and p53, for all cases, and class III beta-tubulin for cases treated with paclitaxel. The findings were correlated with response according to Response Criteria in Solid Tumors; recurrence-free, disease-specific survival; and established prognostic markers. Results: The mean age of 149 patients was 64 years (range, 31Y84 years). Distribution of histopathologic subtypes was as follows: 44 endometrioid (30%), 92 serous/clear cell (62%), and 13 carcinosarcomas (8%). In group A, 11 (33%) and 19 patients (58%) showed expression for ERCC1 and p53, respectively. Seven (78%) of nine patients receiving paclitaxel were positive for class III beta-tubulin. There was no correlation between expression of ERCC1, p53, or class III beta-tubulin and recurrence or survival. In group B, 25 (22%) and 61 patients (64%) were positive for ERCC1 and p53, respectively. Fifty-two (74%) of seventy patients receiving paclitaxel were positive for class III beta-tubulin. Only p53 expression correlated with survival (P = 0.01). Conclusions: In contrast to theoretical assumptions, the current study did not reveal evidence that the expression of ERCC1 and class III beta-tubulin predicts response to cytotoxic treatment and patient outcome in endometrial cancer
AB - Background: In non-small cell lung cancer, expression of excision repair cross-complementation group 1 (ERCC1) and p53 correlates with platinum resistance and class III beta-tubulin with resistance to taxanes. The potential to personalize treatment in endometrial cancer remains uninvestigated. Methods: Patients received platinum-based chemotherapy, with or without paclitaxel. Patients were divided into 2 groups: group A (n = 33) consisted of patients with early-stage endometrial cancer treated with adjuvant chemotherapy. Group B (n = 116) included cases with primary advanced or recurrent disease. Immunohistochemistry was performed to analyze the expression of ERCC1 and p53, for all cases, and class III beta-tubulin for cases treated with paclitaxel. The findings were correlated with response according to Response Criteria in Solid Tumors; recurrence-free, disease-specific survival; and established prognostic markers. Results: The mean age of 149 patients was 64 years (range, 31Y84 years). Distribution of histopathologic subtypes was as follows: 44 endometrioid (30%), 92 serous/clear cell (62%), and 13 carcinosarcomas (8%). In group A, 11 (33%) and 19 patients (58%) showed expression for ERCC1 and p53, respectively. Seven (78%) of nine patients receiving paclitaxel were positive for class III beta-tubulin. There was no correlation between expression of ERCC1, p53, or class III beta-tubulin and recurrence or survival. In group B, 25 (22%) and 61 patients (64%) were positive for ERCC1 and p53, respectively. Fifty-two (74%) of seventy patients receiving paclitaxel were positive for class III beta-tubulin. Only p53 expression correlated with survival (P = 0.01). Conclusions: In contrast to theoretical assumptions, the current study did not reveal evidence that the expression of ERCC1 and class III beta-tubulin predicts response to cytotoxic treatment and patient outcome in endometrial cancer
U2 - https://doi.org/10.1097/IGC.0b013e318218f28b
DO - https://doi.org/10.1097/IGC.0b013e318218f28b
M3 - Article
C2 - 21792013
SN - 1048-891X
VL - 21
SP - 1071
EP - 1077
JO - International journal of gynecological cancer
JF - International journal of gynecological cancer
IS - 6
ER -