Expression of Irx6 during mouse morphogenesis

J. Mummenhoff; A. C. Houweling; T. Peters; V. M. Christoffels; U. Rüther

doi:https://doi.org/10.1016/S0925-4773(01)00353-7

Expression of Irx6 during mouse morphogenesis

J. Mummenhoff, A. C. Houweling, T. Peters, V. M. Christoffels, U. Rüther

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower

Original language	English
Pages (from-to)	193-195
Number of pages	3
Journal	Mechanisms of development
Volume	103
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(01)00353-7
Publication status	Published - May 2001

Keywords

Eye
Heart
Iroquois
Limb development
Mammary glands
Neural tube

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title = "Expression of Irx6 during mouse morphogenesis",

abstract = "Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower",

keywords = "Eye, Heart, Iroquois, Limb development, Mammary glands, Neural tube",

author = "J. Mummenhoff and Houweling, {A. C.} and T. Peters and Christoffels, {V. M.} and U. R{\"u}ther",

note = "Funding Information: We thank Lars Grotewold for critical reading of the manuscript. This work was supported by a grant to U.R. from the DFG (Ru 376/8). A.C.H. and V.M.C. are supported by The Netherlands Heart Foundation grant M96.002.",

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AU - Mummenhoff, J.

AU - Houweling, A. C.

AU - Peters, T.

AU - Christoffels, V. M.

AU - Rüther, U.

N1 - Funding Information: We thank Lars Grotewold for critical reading of the manuscript. This work was supported by a grant to U.R. from the DFG (Ru 376/8). A.C.H. and V.M.C. are supported by The Netherlands Heart Foundation grant M96.002.

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N2 - Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower

AB - Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower

KW - Eye

KW - Heart

KW - Iroquois

KW - Limb development

KW - Mammary glands

KW - Neural tube

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SN - 0925-4773

VL - 103

SP - 193

EP - 195

JO - Mechanisms of development

JF - Mechanisms of development

IS - 1-2

ER -

Expression of Irx6 during mouse morphogenesis

Abstract

Keywords

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