Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine

S. T. Pals; P. Drillenburg; B. Dragosics; A. I. Lazarovits; T. Radaszkiewicz

doi:https://doi.org/10.1016/0016-5085(94)90558-4

Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine

S. T. Pals, P. Drillenburg, B. Dragosics, A. I. Lazarovits, T. Radaszkiewicz

Other Departments

Research output: Contribution to journal › Comment/Letter to the editor › Academic

34 Citations (Scopus)

Abstract

Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP

Original language	English
Pages (from-to)	1519-1523
Journal	Gastroenterology
Volume	107
Issue number	5
DOIs	https://doi.org/10.1016/0016-5085(94)90558-4
Publication status	Published - 1994

Access to Document

https://doi.org/10.1016/0016-5085(94)90558-4

Cite this

@article{8f9cdc55749341d5b5ba5d42bfa7c746,

title = "Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine",

abstract = "Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP",

author = "Pals, {S. T.} and P. Drillenburg and B. Dragosics and Lazarovits, {A. I.} and T. Radaszkiewicz",

year = "1994",

doi = "https://doi.org/10.1016/0016-5085(94)90558-4",

language = "English",

volume = "107",

pages = "1519--1523",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine

AU - Pals, S. T.

AU - Drillenburg, P.

AU - Dragosics, B.

AU - Lazarovits, A. I.

AU - Radaszkiewicz, T.

PY - 1994

Y1 - 1994

N2 - Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP

AB - Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP

U2 - https://doi.org/10.1016/0016-5085(94)90558-4

DO - https://doi.org/10.1016/0016-5085(94)90558-4

M3 - Comment/Letter to the editor

C2 - 7926516

SN - 0016-5085

VL - 107

SP - 1519

EP - 1523

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -