TY - JOUR
T1 - Extracellular matrix composition in COPD
AU - Annoni, Raquel
AU - Lanças, Tatiana
AU - Yukimatsu Tanigawa, Ryan
AU - de Medeiros Matsushita, Marcus
AU - de Morais Fernezlian, Sandra
AU - Bruno, Andreina
AU - Fernando Ferraz da Silva, Luiz
AU - Roughley, Peter J.
AU - Battaglia, Salvatore
AU - Dolhnikoff, Marisa
AU - Hiemstra, Pieter S.
AU - Sterk, Peter J.
AU - Rabe, Klaus F.
AU - Mauad, Thais
PY - 2012
Y1 - 2012
N2 - Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 nonsmoking control subjects. The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and nonsmoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in nonsmokers. Compared with nonsmokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters. Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction
AB - Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 nonsmoking control subjects. The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and nonsmoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in nonsmokers. Compared with nonsmokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters. Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction
U2 - https://doi.org/10.1183/09031936.00192611
DO - https://doi.org/10.1183/09031936.00192611
M3 - Article
C2 - 22496324
SN - 0903-1936
VL - 40
SP - 1362
EP - 1373
JO - European respiratory journal
JF - European respiratory journal
IS - 6
ER -