TY - JOUR
T1 - Extracellular vesicles
T2 - Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities
AU - Pourali, Ghazaleh
AU - Zafari, Nima
AU - Fiuji, Hamid
AU - Batra, Jyotsna
AU - Nazari, Elham
AU - Khazaei, Majid
AU - Hassanian, Seyed Mahdi
AU - Vahabi, Mahrou
AU - Kiani, MohammadAli
AU - Ghayour-Mobarhan, Majid
AU - Peters, Godefridus J.
AU - Ferns, Gordon A.
AU - Lam, Alfred King-yin
AU - Giovannetti, Elisa
AU - Avan, Amir
N1 - Funding Information: Funded by National Institute for Medical Research and Development (NIMAD 962782AA ); NHMRC – National Health and Medical Research Council (AA) and Dutch Cancer Society (EG); JB is supported by Advance Queensland Senior Industry Research Fellowship . Funding Information: Prof. G Ferns from University of Sussex, UK trained in Chemical Pathology at St Bartholomew’s Hospital, London, where he also undertook the research for his MD, funded by a Wellcome Pathology Research Fellowship and Aylwen Research Bursary. He was a British Heart Foundation-American Heart Association Reciprocal Fellow in the Department of Pathology at the University of Washington, Seattle, US, returning to the UK as a Senior Scientist at the William Harvey Research Institute, London. He was appointed Senior Lecturer in Chemical Pathology at the University of Leicester, and then to a Chair in Metabolic & Molecular Medicine at the University of Surrey. He was subsequently Dean of Medicine at the University of Surrey, before his move to the University of Keele Medical School, where he was Director of the Institute of Science and Technology in Medicine. Gordon has worked at BSMS since 2012 as Head of the Department of Medical Education, and Honorary Consultant in Metabolic Medicine. Publisher Copyright: © 2023 The Authors
PY - 2023/10
Y1 - 2023/10
N2 - There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.
AB - There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.
KW - Exosomal cargos
KW - Extracellular vesicles
KW - Gastrointestinal cancers
KW - Hepatopancreatobiliary cancer
KW - Metabolic reprogramming
KW - Tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85168352278&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cytogfr.2023.08.001
DO - https://doi.org/10.1016/j.cytogfr.2023.08.001
M3 - Review article
C2 - 37573251
SN - 1359-6101
VL - 73
SP - 101
EP - 113
JO - Cytokine & Growth Factor Reviews
JF - Cytokine & Growth Factor Reviews
ER -