Extracting the haemodynamic response function from fMRI time series using Fourier-wavelet regularised deconvolution with orthogonal spline wavelets

Alle Meije Wink, Jos B T M Roerdink

Research output: Contribution to conferencePosterAcademic


We describe a method to extract the haemodynamic response function (HRF) from functional magnetic resonance imaging (fMRI) time series based on Fourier-wavelet regularised deconvolution (ForWaRD), and introduce a simple model for the HRF. The HRF extraction algorithm extends the ForWaRD algorithm by introducing a more efficient computation in the case of very long wavelet filters. We compute shift-invariant discrete wavelet transforms (SIDWT) in the frequency domain, and apply ForWaRD using orthogonal spline wavelets. Extraction and modelling of subject-specific HRFs is demonstrated, as well as the use of these HRFs in a subsequent brain activation analysis. Temporal responses are predicted by using the extracted HRF coefficients. The resulting activation maps show the effectiveness of the proposed method.

Original languageEnglish
Publication statusPublished - 1 Dec 2006
Event14th European Signal Processing Conference, EUSIPCO 2006 - Florence, Italy
Duration: 4 Sept 20068 Sept 2006


Conference14th European Signal Processing Conference, EUSIPCO 2006

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