TY - GEN
T1 - Extraction of coronary vascular tree and myocardial perfusion data from stacks of cryomicrotome images
AU - Van Horssen, Pepijn
AU - Van Den Wijngaard, Jeroen P.H.M.
AU - Nolte, Froukje
AU - Hoefer, Imo
AU - Haverslag, Rene
AU - Spaan, Jos A.E.
AU - Siebes, Maria
PY - 2009
Y1 - 2009
N2 - Computational models of myocardial perfusion in normal as well as pathological conditions have contributed to recent advances in the personalized diagnosis and treatment of cardiovascular disease.. For the coronary circulation we attempt to develop a vascular tree model based on realistic replicas from the intramural vessels in hearts from animals and man. These virtual replicas are obtained by means of a novel imaging cryomicrotome producing a stack of 4000 images of 2000x2000 pixels. This paper describes the methods developed for segmentation of the images resulting in a 3D virtual vascular model. Also the methods for fluorescent microsphere detection are described used to validate the models in prediction of flow distribution over the walls of the heart chambers. Special attention is provided to the detection of collaterals and collateral flow.
AB - Computational models of myocardial perfusion in normal as well as pathological conditions have contributed to recent advances in the personalized diagnosis and treatment of cardiovascular disease.. For the coronary circulation we attempt to develop a vascular tree model based on realistic replicas from the intramural vessels in hearts from animals and man. These virtual replicas are obtained by means of a novel imaging cryomicrotome producing a stack of 4000 images of 2000x2000 pixels. This paper describes the methods developed for segmentation of the images resulting in a 3D virtual vascular model. Also the methods for fluorescent microsphere detection are described used to validate the models in prediction of flow distribution over the walls of the heart chambers. Special attention is provided to the detection of collaterals and collateral flow.
KW - Centerline extraction
KW - Coronary collateral flow
KW - Imaging cryomicrotome
KW - Myocardial perfusion
UR - http://www.scopus.com/inward/record.url?scp=68849119485&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-3-642-01932-6_52
DO - https://doi.org/10.1007/978-3-642-01932-6_52
M3 - Conference contribution
SN - 3642019315
SN - 9783642019319
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 486
EP - 494
BT - Functional Imaging and Modeling of the Heart - 5th International Conference, FIMH 2009, Proceedings
T2 - 5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009
Y2 - 3 June 2009 through 5 June 2009
ER -