TY - JOUR
T1 - Extravascular lung water to blood volume ratios as measures of permeability in sepsis-induced ALI/ARDS
AU - Groeneveld, A. B.Johan
AU - Verheij, Joanne
PY - 2006/9
Y1 - 2006/9
N2 - Objective: We studied the relationship, and the effect of fluid loading on this, between the ratio of extravascular lung water (EVLW) to intrathoracic/pulmonary blood volumes (ITBV, PBV) and the radionuclide pulmonary leak index (PLI) to protein during sepsis-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Design and setting: A prospective observational study, in the intensive care unit of a university hospital. Patients: Twenty-two consecutive mechanically ventilated patients with sepsis-related ALI/ARDS from pneumonia (n = 12) or extrapulmonary sources (n = 10), without elevated cardiac filling pressures. Intervention: Crystalloid (1700-1800 ml) or colloid (1000-1800 ml) fluid loading until target filling pressures. Measurements and results: Protein permeability was assessed noninvasively over the lungs with help of 67Ga-labeled transferrin and 99mTc-labeled red blood cells (Pulmonary leak index, upper limit normal 14.1 × 10-3 /min) and EVLW and blood volumes by the thermal-dye transpulmonary dilution technique before and after fluid loading. Prior to fluids the pulmonary leak index related to the ratio of EVLW/ITBV and EVLW/PBV (r s = 0.46) particularly when the pulmonary leak index was below 100 × 10-3 /min and in extrapulmonary sepsis (PLI vs. EVLW/PBV r s = 0.71). Fluid loading did not alter EVLW, EVLW/ITBV, or EVLW/PBV or the relationship to PLI. Conclusion: The data demonstrate that EVLW/ITBV or EVLW/PBV are imperfect measures of increased protein permeability in mechanically ventilated patients with sepsis-induced ALI/ARDS particularly when the PLI is severely increased and during pneumonia, independent of fluid status.
AB - Objective: We studied the relationship, and the effect of fluid loading on this, between the ratio of extravascular lung water (EVLW) to intrathoracic/pulmonary blood volumes (ITBV, PBV) and the radionuclide pulmonary leak index (PLI) to protein during sepsis-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Design and setting: A prospective observational study, in the intensive care unit of a university hospital. Patients: Twenty-two consecutive mechanically ventilated patients with sepsis-related ALI/ARDS from pneumonia (n = 12) or extrapulmonary sources (n = 10), without elevated cardiac filling pressures. Intervention: Crystalloid (1700-1800 ml) or colloid (1000-1800 ml) fluid loading until target filling pressures. Measurements and results: Protein permeability was assessed noninvasively over the lungs with help of 67Ga-labeled transferrin and 99mTc-labeled red blood cells (Pulmonary leak index, upper limit normal 14.1 × 10-3 /min) and EVLW and blood volumes by the thermal-dye transpulmonary dilution technique before and after fluid loading. Prior to fluids the pulmonary leak index related to the ratio of EVLW/ITBV and EVLW/PBV (r s = 0.46) particularly when the pulmonary leak index was below 100 × 10-3 /min and in extrapulmonary sepsis (PLI vs. EVLW/PBV r s = 0.71). Fluid loading did not alter EVLW, EVLW/ITBV, or EVLW/PBV or the relationship to PLI. Conclusion: The data demonstrate that EVLW/ITBV or EVLW/PBV are imperfect measures of increased protein permeability in mechanically ventilated patients with sepsis-induced ALI/ARDS particularly when the PLI is severely increased and during pneumonia, independent of fluid status.
KW - Acute respiratory distress syndrome
KW - Extrapulmonary sepsis
KW - Extravascular lung water
KW - Lung edema
KW - Pneumonia
KW - Pulmonary protein leak index
UR - http://www.scopus.com/inward/record.url?scp=33747587836&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00134-006-0212-8
DO - https://doi.org/10.1007/s00134-006-0212-8
M3 - Article
C2 - 16741694
SN - 0342-4642
VL - 32
SP - 1315
EP - 1321
JO - Intensive care medicine
JF - Intensive care medicine
IS - 9
ER -