TY - JOUR
T1 - Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice
AU - Jakulj, Lily
AU - Vissers, Maud N.
AU - van Roomen, Cindy P.
AU - van der Veen, Jelske N.
AU - Vrins, Carlos L. J.
AU - Kunne, Cindy
AU - Stellaard, Frans
AU - Kastelein, John J. P.
AU - Groen, Albert K.
PY - 2010
Y1 - 2010
N2 - Ezetimibe stimulates faecal neutral sterol (FNS) excretion in mice, which cannot be explained by cholesterol absorption inhibition alone. We investigated whether these effects are mediated via the sterol exporter ATP binding cassette transporter G8 (abcg8). Ezetimibe increased FNS excretion 2.7-fold in WT mice and 1.5-fold in abcg8(-/-) mice, without affecting biliary cholesterol secretion. Daily FNS excretion exceeded the sum of dietary cholesterol intake and biliary secretion by about 60%. Ezetimibe enhanced this 'extra' FNS excretion by 3.5-fold and 1.5-fold in wildtype (WT) and abcg8(-/-)mice, respectively. Ezetimibe stimulates fecal sterol excretion of non-biliary and non-dietary origin, probably through stimulation of trans-intestinal cholesterol excretion. We show that this effect depends on intact abcg8 function. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved
AB - Ezetimibe stimulates faecal neutral sterol (FNS) excretion in mice, which cannot be explained by cholesterol absorption inhibition alone. We investigated whether these effects are mediated via the sterol exporter ATP binding cassette transporter G8 (abcg8). Ezetimibe increased FNS excretion 2.7-fold in WT mice and 1.5-fold in abcg8(-/-) mice, without affecting biliary cholesterol secretion. Daily FNS excretion exceeded the sum of dietary cholesterol intake and biliary secretion by about 60%. Ezetimibe enhanced this 'extra' FNS excretion by 3.5-fold and 1.5-fold in wildtype (WT) and abcg8(-/-)mice, respectively. Ezetimibe stimulates fecal sterol excretion of non-biliary and non-dietary origin, probably through stimulation of trans-intestinal cholesterol excretion. We show that this effect depends on intact abcg8 function. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved
U2 - https://doi.org/10.1016/j.febslet.2010.07.035
DO - https://doi.org/10.1016/j.febslet.2010.07.035
M3 - Article
C2 - 20659465
SN - 0014-5793
VL - 584
SP - 3625
EP - 3628
JO - FEBS letters
JF - FEBS letters
IS - 16
ER -