TY - JOUR
T1 - Factors associated with swallowing dysfunction in patients with head and neck cancer
AU - Vermaire, Jorine A.
AU - Raaijmakers, Cornelis P. J.
AU - Monninkhof, Evelyn M.
AU - Verdonck-de Leeuw, Irma M.
AU - Terhaard, Chris H. J.
AU - Speksnijder, Caroline M.
N1 - Funding Information: This study was carried out using the research infrastructure within the NET‐QUBIC project (NETherlands QUality of life and Biomedical Cohort studies in Head and Neck Cancer) sponsored by the Dutch Cancer Society/Alpe d’HuZes (grant number 2013.301(A2018.307)‐NL45051.029.13) Funding Information: We thank all patients for participating in this research. This study was carried out using the research infrastructure within the NET‐QUBIC project (NETherlands QUality of life and BIomedical Cohort studies in Head and Neck Cancer) sponsored by the Dutch Cancer Society/Alpe d’HuZes. Publisher Copyright: © 2022 The Authors. Oral Diseases published by Wiley Periodicals LLC.
PY - 2022
Y1 - 2022
N2 - Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment. Methods: The 100 ml water swallow test was measured before treatment, and 3, 6, 12, and 24 months after treatment. Linear mixed-effects model analysis was conducted to investigate changes over time and the association with personal (sex and age) and clinical (tumor site, tumor stage, and treatment modality) factors. Results: Among 128 included patients, number of swallows increased from baseline to 3 months after treatment and decreased to baseline again at 6 months after treatment. The number of swallows was associated with age and treatment modality. Conclusions: In patients with HNC, swallowing (dys)function changes over time with the worst score 3 months after treatment. A higher age and being treated with surgery are factors associated with swallowing dysfunction over time.
AB - Background: The aim of this prospective cohort study was to investigate swallowing function in relation to personal and clinical factors among patients with head and neck cancer (HNC) from diagnosis up to 2 years after treatment. Methods: The 100 ml water swallow test was measured before treatment, and 3, 6, 12, and 24 months after treatment. Linear mixed-effects model analysis was conducted to investigate changes over time and the association with personal (sex and age) and clinical (tumor site, tumor stage, and treatment modality) factors. Results: Among 128 included patients, number of swallows increased from baseline to 3 months after treatment and decreased to baseline again at 6 months after treatment. The number of swallows was associated with age and treatment modality. Conclusions: In patients with HNC, swallowing (dys)function changes over time with the worst score 3 months after treatment. A higher age and being treated with surgery are factors associated with swallowing dysfunction over time.
KW - 100 ml water swallowing test
KW - head and neck cancer
KW - linear mixed model
KW - swallowing dysfunction
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127238652&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35298058
U2 - https://doi.org/10.1111/odi.14192
DO - https://doi.org/10.1111/odi.14192
M3 - Article
C2 - 35298058
SN - 1354-523X
JO - Oral diseases
JF - Oral diseases
ER -