Failing immune control as a result of impaired CD8(+) T-cell maturation: CD27 might provide a clue

Debbie van Baarle; Stefan Kostense; Marinus H. J. van Oers; Dorte Hamann; Frank Miedema

doi:https://doi.org/10.1016/S1471-4906(02)02326-8

Failing immune control as a result of impaired CD8(+) T-cell maturation: CD27 might provide a clue

Debbie van Baarle, Stefan Kostense, Marinus H. J. van Oers, Dorte Hamann, Frank Miedema

Research output: Contribution to journal › Article › Academic › peer-review

111 Citations (Scopus)

Abstract

Despite readily detectable virus-specific CD8(+)T cells inmost HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development

Original language	English
Pages (from-to)	586-591
Journal	Trends in immunology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/S1471-4906(02)02326-8
Publication status	Published - 2002

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https://doi.org/10.1016/S1471-4906(02)02326-8

Cite this

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title = "Failing immune control as a result of impaired CD8(+) T-cell maturation: CD27 might provide a clue",

abstract = "Despite readily detectable virus-specific CD8(+)T cells inmost HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development",

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AU - Kostense, Stefan

AU - van Oers, Marinus H. J.

AU - Hamann, Dorte

AU - Miedema, Frank

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AB - Despite readily detectable virus-specific CD8(+)T cells inmost HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development

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