Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

T. Kraft; E.R. Witjas-Paalberends; N. Boontje; S. Tripathi; A. Brandis; J. Montag; J.L. Hodgkinson; A. Francino; F. Navarro-Lopez; B. Brenner; G.J.M. Stienen; J. van der Velden

doi:https://doi.org/10.1016/j.yjmcc.2013.01.001

Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

T. Kraft, E.R. Witjas-Paalberends, N. Boontje, S. Tripathi, A. Brandis, J. Montag, J.L. Hodgkinson, A. Francino, F. Navarro-Lopez, B. Brenner, G.J.M. Stienen, J. van der Velden

Physiology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

Familial Hypertrophic Cardiomyopathy (FHC) is frequently caused by mutations in the β-cardiac myosin heavy chain (β-MyHC). To identify changes in sarcomeric function triggered by such mutations, distinguishing mutation effects from other functional alterations of the myocardium is essential. We previously identified a direct effect of mutation R723G (MyHC

Original language	English
Pages (from-to)	13-22
Journal	Journal of molecular and cellular cardiology
Volume	57
DOIs	https://doi.org/10.1016/j.yjmcc.2013.01.001
Publication status	Published - 2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.yjmcc.2013.01.001

Cite this

Kraft, T., Witjas-Paalberends, E. R., Boontje, N., Tripathi, S., Brandis, A., Montag, J., Hodgkinson, J. L., Francino, A., Navarro-Lopez, F., Brenner, B., Stienen, G. J. M., & van der Velden, J. (2013). Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes. Journal of molecular and cellular cardiology, 57, 13-22. https://doi.org/10.1016/j.yjmcc.2013.01.001

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Kraft, T, Witjas-Paalberends, ER, Boontje, N, Tripathi, S, Brandis, A, Montag, J, Hodgkinson, JL, Francino, A, Navarro-Lopez, F, Brenner, B, Stienen, GJM & van der Velden, J 2013, 'Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes', Journal of molecular and cellular cardiology, vol. 57, pp. 13-22. https://doi.org/10.1016/j.yjmcc.2013.01.001

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AU - Kraft, T.

AU - Witjas-Paalberends, E.R.

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AU - Tripathi, S.

AU - Brandis, A.

AU - Montag, J.

AU - Hodgkinson, J.L.

AU - Francino, A.

AU - Navarro-Lopez, F.

AU - Brenner, B.

AU - Stienen, G.J.M.

AU - van der Velden, J.

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AB - Familial Hypertrophic Cardiomyopathy (FHC) is frequently caused by mutations in the β-cardiac myosin heavy chain (β-MyHC). To identify changes in sarcomeric function triggered by such mutations, distinguishing mutation effects from other functional alterations of the myocardium is essential. We previously identified a direct effect of mutation R723G (MyHC

U2 - https://doi.org/10.1016/j.yjmcc.2013.01.001

DO - https://doi.org/10.1016/j.yjmcc.2013.01.001

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