TY - JOUR
T1 - Family History Is Associated with Phenotype in Dementia with Lewy Bodies
AU - Vergouw, Leonie J. M.
AU - Bosman, Brechje
AU - van de Beek, Marleen
AU - Salomé, Mariet
AU - Hoogers, Susanne E.
AU - van Steenoven, Inger
AU - Roks, Gerwin
AU - Bonifati, Vincenzo
AU - van Swieten, John C.
AU - Lemstra, Afina W.
AU - de Jong, Frank Jan
PY - 2020
Y1 - 2020
N2 - It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson's disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and Alzheimer's disease (AD) biomarkers in patients with familial DLB (n = 154) and sporadic DLB (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p≤0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis.
AB - It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson's disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and Alzheimer's disease (AD) biomarkers in patients with familial DLB (n = 154) and sporadic DLB (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p≤0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis.
KW - Dementia with Lewy bodies
KW - family history
KW - phenotype
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85077792753&partnerID=8YFLogxK
U2 - https://doi.org/10.3233/JAD-190825
DO - https://doi.org/10.3233/JAD-190825
M3 - Article
C2 - 31771063
SN - 1387-2877
VL - 73
SP - 269
EP - 275
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -