TY - JOUR
T1 - Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata
AU - Reekie, Joanne
AU - Gatell, Jose M.
AU - Yust, Israel
AU - Bakowska, Elzbieta
AU - Rakhmanova, Aza
AU - Losso, Marcelo
AU - Krasnov, Maksym
AU - Francioli, Patrick
AU - Kowalska, Justyna D.
AU - Mocroft, Amanda
AU - AUTHOR GROUP
AU - Elias, C.
AU - Hospital, J. M.
AU - Mejia, Ramos
AU - Aires, Buenos
AU - Vetter, N.
AU - Zangerle, R.
AU - Karpov, I.
AU - Vassilenko, A.
AU - Mitsura, V. M.
AU - Suetnov, O.
AU - Clumeck, N.
AU - de Wit, S.
AU - Delforge, M.
AU - Colebunders, R.
AU - Vandekerckhove, L.
AU - Hadziosmanovic, V.
AU - Kostov, K.
AU - Begovac, J.
AU - Machala, L.
AU - Jilich, D.
AU - Sedlacek, D.
AU - Nielsen, J.
AU - Kronborg, G.
AU - Benfield, Y.
AU - Larsen, M.
AU - Gerstoft, J.
AU - Katzenstein, T.
AU - Hansen, A. B. E.
AU - Skinhøj, P.
AU - Pedersen, C.
AU - Ostergaard, L.
AU - Zilmer, K.
AU - Smidt, J.
AU - Ristola, M.
AU - Viard, J. P.
AU - Girard, P. M.
AU - Livrozet, J. M.
AU - Vanhems, P.
AU - Pradier, C.
AU - Reiss, P.
PY - 2011
Y1 - 2011
N2 - This study compared the incidence of fatal and nonfatal AIDS and non-AIDS events in HIV-positive individuals with a CD4 cell count more than 350 cells/μl among viral load strata: low ( <500 copies/ml), intermediate (500-9999.9 copies/ml) and high (≥ 10000 copies/ml). Individuals contributed person-years at risk if their most recent CD4 cell count was more than 350 cells/μl. Follow-up was censored if their CD4 cell count dropped below 350 cells/μl. Poisson regression analysis investigated the relationship between viraemia and the incidence of AIDS and non-AIDS events. Three hundred and fifty-four AIDS events occurred during 51 732 person-years of follow-up (PYFU), crude incidence rate of AIDS across the three strata was 0.53, 0.90 and 2.12 per 100 PYFU, respectively. After adjustment, a higher rate of AIDS was observed in individuals with moderate [incidence rate ratio (IRR) 1.44, 1.02-2.05, P = 0.03] and high viraemia had a higher rate (IRR 3.91, 2.89-5.89, P < 0.0001) compared with low viraemia. Five hundred and seventy-two non-AIDS events occurred during 43 784 PYFU, the crude incidence rates were 1.28, 1.52, and 1.38 per 100 PYFU, respectively. After adjustment, particularly for age, region of Europe and starting combination antiretroviral therapy, there was a 61% (IRR 1.61, 1.21-2.14, P = 0.001) and 66% (IRR 1.66, 1.17-2.32, P = 0.004) higher rate of non-AIDS in individuals with intermediate and high viraemia compared with low viraemia. In individuals with a CD4 cell count more than 350 cells/μl, an increased incidence of AIDS and a slightly increased incidence of non-AIDS was found in those with uncontrolled viral replication. The association with AIDS was clear and consistent. However, the association with non-AIDS was only apparent after adjustment and no differences were observed between intermediate and high viraemia
AB - This study compared the incidence of fatal and nonfatal AIDS and non-AIDS events in HIV-positive individuals with a CD4 cell count more than 350 cells/μl among viral load strata: low ( <500 copies/ml), intermediate (500-9999.9 copies/ml) and high (≥ 10000 copies/ml). Individuals contributed person-years at risk if their most recent CD4 cell count was more than 350 cells/μl. Follow-up was censored if their CD4 cell count dropped below 350 cells/μl. Poisson regression analysis investigated the relationship between viraemia and the incidence of AIDS and non-AIDS events. Three hundred and fifty-four AIDS events occurred during 51 732 person-years of follow-up (PYFU), crude incidence rate of AIDS across the three strata was 0.53, 0.90 and 2.12 per 100 PYFU, respectively. After adjustment, a higher rate of AIDS was observed in individuals with moderate [incidence rate ratio (IRR) 1.44, 1.02-2.05, P = 0.03] and high viraemia had a higher rate (IRR 3.91, 2.89-5.89, P < 0.0001) compared with low viraemia. Five hundred and seventy-two non-AIDS events occurred during 43 784 PYFU, the crude incidence rates were 1.28, 1.52, and 1.38 per 100 PYFU, respectively. After adjustment, particularly for age, region of Europe and starting combination antiretroviral therapy, there was a 61% (IRR 1.61, 1.21-2.14, P = 0.001) and 66% (IRR 1.66, 1.17-2.32, P = 0.004) higher rate of non-AIDS in individuals with intermediate and high viraemia compared with low viraemia. In individuals with a CD4 cell count more than 350 cells/μl, an increased incidence of AIDS and a slightly increased incidence of non-AIDS was found in those with uncontrolled viral replication. The association with AIDS was clear and consistent. However, the association with non-AIDS was only apparent after adjustment and no differences were observed between intermediate and high viraemia
U2 - https://doi.org/10.1097/QAD.0b013e32834cdb4b
DO - https://doi.org/10.1097/QAD.0b013e32834cdb4b
M3 - Article
C2 - 21918422
SN - 0269-9370
VL - 25
SP - 2259
EP - 2268
JO - AIDS (London, England)
JF - AIDS (London, England)
IS - 18
ER -