Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

M. J. Taphoorn, E. van Someren, F. J. Snoek, R. L. Strijers, D. F. Swaab, F. Visscher, L. P. de Waal, C. H. Polman

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The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients
Original languageEnglish
Pages (from-to)446-448
Number of pages3
JournalJournal of neurology
Issue number7
Publication statusPublished - 1 Jul 1993


  • Circadian rhythm
  • Fatigue
  • Multiple sclerosis
  • Sleep

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