Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

M. J. Taphoorn; E. van Someren; F. J. Snoek; R. L. Strijers; D. F. Swaab; F. Visscher; L. P. de Waal; C. H. Polman

doi:https://doi.org/10.1007/BF00867360

Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

M. J. Taphoorn, E. van Someren, F. J. Snoek, R. L. Strijers, D. F. Swaab, F. Visscher, L. P. de Waal, C. H. Polman

Research output: Contribution to journal › Article › Academic › peer-review

79 Citations (Scopus)

Abstract

The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients

Original language	English
Pages (from-to)	446-448
Number of pages	3
Journal	Journal of neurology
Volume	240
Issue number	7
DOIs	https://doi.org/10.1007/BF00867360
Publication status	Published - 1 Jul 1993

Keywords

Circadian rhythm
Fatigue
Multiple sclerosis
Sleep

Access to Document

https://doi.org/10.1007/BF00867360

Cite this

@article{eaa7fc8160f94a3c9729df1ef543431c,

title = "Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis",

abstract = "The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients",

keywords = "Circadian rhythm, Fatigue, Multiple sclerosis, Sleep",

author = "Taphoorn, {M. J.} and {van Someren}, E. and Snoek, {F. J.} and Strijers, {R. L.} and Swaab, {D. F.} and F. Visscher and {de Waal}, {L. P.} and Polman, {C. H.}",

year = "1993",

month = jul,

day = "1",

doi = "https://doi.org/10.1007/BF00867360",

language = "English",

volume = "240",

pages = "446--448",

journal = "Journal of neurology",

issn = "0340-5354",

publisher = "D. Steinkopff-Verlag",

number = "7",

}

TY - JOUR

T1 - Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

AU - Taphoorn, M. J.

AU - van Someren, E.

AU - Snoek, F. J.

AU - Strijers, R. L.

AU - Swaab, D. F.

AU - Visscher, F.

AU - de Waal, L. P.

AU - Polman, C. H.

PY - 1993/7/1

Y1 - 1993/7/1

N2 - The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients

AB - The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients

KW - Circadian rhythm

KW - Fatigue

KW - Multiple sclerosis

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=0027169042&partnerID=8YFLogxK

U2 - https://doi.org/10.1007/BF00867360

DO - https://doi.org/10.1007/BF00867360

M3 - Article

C2 - 8410088

SN - 0340-5354

VL - 240

SP - 446

EP - 448

JO - Journal of neurology

JF - Journal of neurology

IS - 7

ER -

Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

Abstract

Keywords

Access to Document

Other files and links

Cite this