TY - JOUR
T1 - Fatty Acid Oxidation in Macrophages and T Cells
T2 - Time for Reassessment?
AU - Van den Bossche, Jan
AU - van der Windt, Gerritje J W
PY - 2018/10/2
Y1 - 2018/10/2
N2 - Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes.
AB - Previous immunometabolism research using the CPT1 inhibitor etomoxir suggests that long-chain fatty acid oxidation (LC-FAO) supports IL-4-driven alternative macrophage activation (M(IL-4)) and regulates memory and regulatory T cell formation. Divakaruni et al. (2018) and Raud et al. (2018) now report that LC-FAO is largely dispensable for these processes.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053941845&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30282046
U2 - https://doi.org/10.1016/j.cmet.2018.09.018
DO - https://doi.org/10.1016/j.cmet.2018.09.018
M3 - Article
C2 - 30282046
SN - 1550-4131
VL - 28
SP - 538
EP - 540
JO - Cell metabolism
JF - Cell metabolism
IS - 4
ER -