TY - JOUR
T1 - Fetal Growth Restriction
T2 - Mechanisms, Epidemiology, and Management
AU - Kamphof, Hester D.
AU - Posthuma, Selina
AU - Gordijn, Sanne J.
AU - Ganzevoort, Wessel
N1 - Publisher Copyright: © 2022 Maternal-Fetal Medicine. All right reserved.
PY - 2022/7/22
Y1 - 2022/7/22
N2 - AbstractFetal growth restriction (FGR) is the condition in which a fetus does not reach its intrinsic growth potential and in which the short-term and long-term risks of severe complications are increased. FGR is a frequent complication of pregnancy with a complex etiology and limited management options, other than timely delivery. The most common pathophysiological mechanism is placental insufficiency, due to many underlying causes such as maternal vascular malperfusion, fetal vascular malperfusion and villitis.Identifying truly growth restricted fetuses remains challenging. To date, FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard. However, small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes. In 2016, the consensus definition of FGR was internationally accepted to better pinpoint the FGR population.In this review we will discuss the contemporary diagnosis and management issues. Different diagnostic markers are considered, like Doppler measurements, estimated fetal growth, interval growth, fetal movements, biomarkers, and placental markers.
AB - AbstractFetal growth restriction (FGR) is the condition in which a fetus does not reach its intrinsic growth potential and in which the short-term and long-term risks of severe complications are increased. FGR is a frequent complication of pregnancy with a complex etiology and limited management options, other than timely delivery. The most common pathophysiological mechanism is placental insufficiency, due to many underlying causes such as maternal vascular malperfusion, fetal vascular malperfusion and villitis.Identifying truly growth restricted fetuses remains challenging. To date, FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard. However, small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes. In 2016, the consensus definition of FGR was internationally accepted to better pinpoint the FGR population.In this review we will discuss the contemporary diagnosis and management issues. Different diagnostic markers are considered, like Doppler measurements, estimated fetal growth, interval growth, fetal movements, biomarkers, and placental markers.
KW - Biomarkers
KW - Doppler measurements
KW - Fetal growth restriction
KW - Growth restriction in the newborn
KW - Placental function
KW - Placental insufficiency syndrome
UR - http://www.scopus.com/inward/record.url?scp=85135258705&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/FM9.0000000000000161
DO - https://doi.org/10.1097/FM9.0000000000000161
M3 - Review article
SN - 2096-6954
VL - 4
SP - 186
EP - 196
JO - Maternal-Fetal Medicine
JF - Maternal-Fetal Medicine
IS - 3
ER -