Fetal Supraventricular Tachyarrhythmias: Pharmacokinetics, Modes of Action, and Results of Anti-Arrhythmic Drug Therapy

Edgar Jaeggi, Nico A. Blom

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Supraventricular tachycardia (SVT) belongs to the common cardiac causes of fetal heart failure and perinatal death [1]. With the arrival of ultrasound imaging to non-invasively detect cardiac anomalies before birth, the fetus has increasingly become the target of intended prenatal treatment. This includes the off-label administration of pharmaceutical agents via the maternal circulation or directly into the fetus to treat SVT. As anti-arrhythmic drugs act on one or several ion channels, the autonomous system, or both, we will start with an overview of the normal and abnormal electro-mechanical activation of the heart before discussing indications, modes of action, and effects of anti-arrhythmic therapy for fetal SVT.
Original languageEnglish
Title of host publicationFetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits
PublisherCambridge University Press
ISBN (Electronic)9781108564434
ISBN (Print)9781108474061
Publication statusPublished - 1 Jan 2019

Publication series

NameFetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits

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