TY - CHAP
T1 - Fetal Supraventricular Tachyarrhythmias
T2 - Pharmacokinetics, Modes of Action, and Results of Anti-Arrhythmic Drug Therapy
AU - Jaeggi, Edgar
AU - Blom, Nico A.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Supraventricular tachycardia (SVT) belongs to the common cardiac causes of fetal heart failure and perinatal death [1]. With the arrival of ultrasound imaging to non-invasively detect cardiac anomalies before birth, the fetus has increasingly become the target of intended prenatal treatment. This includes the off-label administration of pharmaceutical agents via the maternal circulation or directly into the fetus to treat SVT. As anti-arrhythmic drugs act on one or several ion channels, the autonomous system, or both, we will start with an overview of the normal and abnormal electro-mechanical activation of the heart before discussing indications, modes of action, and effects of anti-arrhythmic therapy for fetal SVT.
AB - Supraventricular tachycardia (SVT) belongs to the common cardiac causes of fetal heart failure and perinatal death [1]. With the arrival of ultrasound imaging to non-invasively detect cardiac anomalies before birth, the fetus has increasingly become the target of intended prenatal treatment. This includes the off-label administration of pharmaceutical agents via the maternal circulation or directly into the fetus to treat SVT. As anti-arrhythmic drugs act on one or several ion channels, the autonomous system, or both, we will start with an overview of the normal and abnormal electro-mechanical activation of the heart before discussing indications, modes of action, and effects of anti-arrhythmic therapy for fetal SVT.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133038134&origin=inward
U2 - https://doi.org/10.1017/9781108564434.018
DO - https://doi.org/10.1017/9781108564434.018
M3 - Chapter
SN - 9781108474061
T3 - Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits
SP - 166
EP - 175
BT - Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits
PB - Cambridge University Press
ER -