TY - JOUR
T1 - Finding hidden treasures in old drugs
T2 - the challenges and importance of licensing generics
AU - Simsek, Melek
AU - Meijer, Berrie
AU - van Bodegraven, Adriaan A.
AU - de Boer, Nanne K.H.
AU - Mulder, Chris J.J.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Identifying new indications for existing drugs creates new therapeutic options while bypassing much of the costs and time involved with bringing a new drug to market. The rediscovery of a generic drug, however, is a challenging pursuit because there is no formal regulatory approach and a lack of economic interest by pharmaceutical companies. This played a part in the re-registration of thioguanine as a rescue drug for the treatment of patients with inflammatory bowel disease in The Netherlands. In this article, we aim to underline the importance of drug rediscovery, the difficulties of this procedure in Europe and we attempt to suggest conceivable solutions.
AB - Identifying new indications for existing drugs creates new therapeutic options while bypassing much of the costs and time involved with bringing a new drug to market. The rediscovery of a generic drug, however, is a challenging pursuit because there is no formal regulatory approach and a lack of economic interest by pharmaceutical companies. This played a part in the re-registration of thioguanine as a rescue drug for the treatment of patients with inflammatory bowel disease in The Netherlands. In this article, we aim to underline the importance of drug rediscovery, the difficulties of this procedure in Europe and we attempt to suggest conceivable solutions.
UR - http://www.scopus.com/inward/record.url?scp=85040285788&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.drudis.2017.08.008
DO - https://doi.org/10.1016/j.drudis.2017.08.008
M3 - Short survey
C2 - 28867540
SN - 1359-6446
VL - 23
SP - 17
EP - 21
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -