First-in-Human Experience With Ultra-Low Temperature Cryoablation for Monomorphic Ventricular Tachycardia

Tom de Potter; Jippe C. Balt; Lucas Boersma; Frederic Sacher; Peter Neuzil; Vivek Reddy; Ilya Grigorov; Atul Verma

doi:https://doi.org/10.1016/j.jacep.2022.11.017

First-in-Human Experience With Ultra-Low Temperature Cryoablation for Monomorphic Ventricular Tachycardia

Tom de Potter, Jippe C. Balt, Lucas Boersma, Frederic Sacher, Peter Neuzil, Vivek Reddy, Ilya Grigorov, Atul Verma

Research output: Contribution to journal › Review article › Academic › peer-review

7 Citations (Scopus)

Abstract

Ultra-low temperature cryoablation (ULTC) using near-critical nitrogen (−196ºC) has been shown to produce durable, contiguous, transmural lesions in ventricles of animal models. This report summarizes acute experience with ULTC in the first-ever 13 patients with recurrent monomorphic ventricular tachycardias (VTs) of both ischemic cardiomyopathy and nonischemic etiologies enrolled in the CryoCure-VT (Cryoablation for Monomorphic Ventricular Tachycardia; NCT04893317) clinical trial. After an average of 9.6 ± 4.6 endocardial ULTC lesions per patient, no clinical ventricular tachycardias were inducible in 91% of patients. Two procedure-related serious adverse events recorded in 2 patients resolved post-procedurally without clinical sequelae. Further investigation of both acute and chronic outcomes is warranted and ongoing.

Original language	English
Pages (from-to)	686-691
Number of pages	6
Journal	JACC: Clinical Electrophysiology
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/j.jacep.2022.11.017
Publication status	Published - 1 May 2023
Externally published	Yes

Keywords

ultra-low temperature cryoablation
ventricular tachycardia ablation

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https://doi.org/10.1016/j.jacep.2022.11.017

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title = "First-in-Human Experience With Ultra-Low Temperature Cryoablation for Monomorphic Ventricular Tachycardia",

abstract = "Ultra-low temperature cryoablation (ULTC) using near-critical nitrogen (−196ºC) has been shown to produce durable, contiguous, transmural lesions in ventricles of animal models. This report summarizes acute experience with ULTC in the first-ever 13 patients with recurrent monomorphic ventricular tachycardias (VTs) of both ischemic cardiomyopathy and nonischemic etiologies enrolled in the CryoCure-VT (Cryoablation for Monomorphic Ventricular Tachycardia; NCT04893317) clinical trial. After an average of 9.6 ± 4.6 endocardial ULTC lesions per patient, no clinical ventricular tachycardias were inducible in 91% of patients. Two procedure-related serious adverse events recorded in 2 patients resolved post-procedurally without clinical sequelae. Further investigation of both acute and chronic outcomes is warranted and ongoing.",

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AU - de Potter, Tom

AU - Balt, Jippe C.

AU - Boersma, Lucas

AU - Sacher, Frederic

AU - Neuzil, Peter

AU - Reddy, Vivek

AU - Grigorov, Ilya

AU - Verma, Atul

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Y1 - 2023/5/1

N2 - Ultra-low temperature cryoablation (ULTC) using near-critical nitrogen (−196ºC) has been shown to produce durable, contiguous, transmural lesions in ventricles of animal models. This report summarizes acute experience with ULTC in the first-ever 13 patients with recurrent monomorphic ventricular tachycardias (VTs) of both ischemic cardiomyopathy and nonischemic etiologies enrolled in the CryoCure-VT (Cryoablation for Monomorphic Ventricular Tachycardia; NCT04893317) clinical trial. After an average of 9.6 ± 4.6 endocardial ULTC lesions per patient, no clinical ventricular tachycardias were inducible in 91% of patients. Two procedure-related serious adverse events recorded in 2 patients resolved post-procedurally without clinical sequelae. Further investigation of both acute and chronic outcomes is warranted and ongoing.

AB - Ultra-low temperature cryoablation (ULTC) using near-critical nitrogen (−196ºC) has been shown to produce durable, contiguous, transmural lesions in ventricles of animal models. This report summarizes acute experience with ULTC in the first-ever 13 patients with recurrent monomorphic ventricular tachycardias (VTs) of both ischemic cardiomyopathy and nonischemic etiologies enrolled in the CryoCure-VT (Cryoablation for Monomorphic Ventricular Tachycardia; NCT04893317) clinical trial. After an average of 9.6 ± 4.6 endocardial ULTC lesions per patient, no clinical ventricular tachycardias were inducible in 91% of patients. Two procedure-related serious adverse events recorded in 2 patients resolved post-procedurally without clinical sequelae. Further investigation of both acute and chronic outcomes is warranted and ongoing.

KW - ultra-low temperature cryoablation

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First-in-Human Experience With Ultra-Low Temperature Cryoablation for Monomorphic Ventricular Tachycardia

Abstract

Keywords

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