TY - JOUR
T1 - Fluorescence in situ hybridization: a multitarget approach in diagnosis and management of urothelial cancer
AU - Arentsen, Harm C.
AU - de La Rosette, Jean J. M. C. H.
AU - de Reijke, Theo M.
AU - Langbein, Sigrun
PY - 2007
Y1 - 2007
N2 - Noninvasive tests for detecting genetic or molecular alterations in urine indicative of urothelial cancer are increasingly becoming the focus of urological cancer research. Since its approval by the US FDA in 2001, the fluorescence in situ hybridization test (Vysis UroVysion) has been widely evaluated. In general, published data demonstrate better sensitivity and equal or better specificity compared with routine cytology, which is still considered the 'gold standard' in diagnosing and monitoring bladder tumors. However, the fluorescence in situ hybridization test seems to provide not only a useful tool in bladder cancer detection, but also in the diagnosis of upper urinary tract tumors, surveillance and determining therapy effectiveness. This multitarget assay that detects four different chromosomal aberrations in tumor cells is a kind of objective molecular cytology and has proven advantages over routinely used cytology
AB - Noninvasive tests for detecting genetic or molecular alterations in urine indicative of urothelial cancer are increasingly becoming the focus of urological cancer research. Since its approval by the US FDA in 2001, the fluorescence in situ hybridization test (Vysis UroVysion) has been widely evaluated. In general, published data demonstrate better sensitivity and equal or better specificity compared with routine cytology, which is still considered the 'gold standard' in diagnosing and monitoring bladder tumors. However, the fluorescence in situ hybridization test seems to provide not only a useful tool in bladder cancer detection, but also in the diagnosis of upper urinary tract tumors, surveillance and determining therapy effectiveness. This multitarget assay that detects four different chromosomal aberrations in tumor cells is a kind of objective molecular cytology and has proven advantages over routinely used cytology
U2 - https://doi.org/10.1586/14737159.7.1.11
DO - https://doi.org/10.1586/14737159.7.1.11
M3 - Review article
C2 - 17187480
SN - 1473-7159
VL - 7
SP - 11
EP - 19
JO - Expert review of molecular diagnostics
JF - Expert review of molecular diagnostics
IS - 1
ER -