TY - JOUR
T1 - Follistatin-like 1 in cardiovascular disease and inflammation
AU - Neef, Klaus
AU - Peters, Marijn M. C.
AU - Meijs, Timion A.
AU - Gathier, Wouter
AU - Doevendans, Pieter A. M.
AU - Sluijter, Joost P. G.
AU - Chamuleau, Steven A. J.
PY - 2019
Y1 - 2019
N2 - Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Spatiotemporal regulation and posttranslational modifications contribute to its specific functions and make it an intriguing candidate to study disease mechanisms and potentially develop new therapies. With cardiovascular diseases as the primary cause of death worldwide, clarification of mechanisms underlying cardiac regeneration and revascularization remains essential. Recent findings on FSTL1 in both acute coronary syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy. With this review, we aim to shed light on the role of FSTL1 specifically in cardiovascular disease and inflammation.
AB - Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Spatiotemporal regulation and posttranslational modifications contribute to its specific functions and make it an intriguing candidate to study disease mechanisms and potentially develop new therapies. With cardiovascular diseases as the primary cause of death worldwide, clarification of mechanisms underlying cardiac regeneration and revascularization remains essential. Recent findings on FSTL1 in both acute coronary syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy. With this review, we aim to shed light on the role of FSTL1 specifically in cardiovascular disease and inflammation.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075114900&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30864520
U2 - https://doi.org/10.2174/1389557519666190312161551
DO - https://doi.org/10.2174/1389557519666190312161551
M3 - Article
C2 - 30864520
SN - 1389-5575
VL - 19
SP - 1379
EP - 1389
JO - Mini reviews in medicinal chemistry
JF - Mini reviews in medicinal chemistry
IS - 16
ER -