TY - JOUR
T1 - Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans
AU - Gao, Arwen W.
AU - uit de Bos, Jelmi
AU - Sterken, Mark G.
AU - Kammenga, Jan E.
AU - Smith, Reuben L.
AU - Houtkooper, Riekelt H.
PY - 2018
Y1 - 2018
N2 - The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes involved in lifespan regulation are associated with metabolic pathways and are influenced by genetic and environmental factors. In line with this, C. elegans provides a promising platform to study such gene by environment interactions, in either a reverse or forward genetics approach. In this review, we discuss longevity mechanisms related to metabolic networks that have been discovered in C. elegans. We also highlight the use of wild populations to study the complex genetic basis of natural variation for quantitative traits that mediate longevity.
AB - The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes involved in lifespan regulation are associated with metabolic pathways and are influenced by genetic and environmental factors. In line with this, C. elegans provides a promising platform to study such gene by environment interactions, in either a reverse or forward genetics approach. In this review, we discuss longevity mechanisms related to metabolic networks that have been discovered in C. elegans. We also highlight the use of wild populations to study the complex genetic basis of natural variation for quantitative traits that mediate longevity.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029711988&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28919364
U2 - https://doi.org/10.1016/j.bbadis.2017.09.006
DO - https://doi.org/10.1016/j.bbadis.2017.09.006
M3 - Review article
C2 - 28919364
SN - 0925-4439
VL - 1864
SP - 2697
EP - 2706
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 9
ER -