TY - THES
T1 - Four-dimensional imaging of scaphoid kinematics
AU - de Roo, Marieke G. A.
PY - 2020
Y1 - 2020
N2 - The human wrist contains eight carpal bones in which the scaphoid plays a key role in carpal stability and mechanics. A scaphoid fracture is the most common carpal fracture. When healing of the fracture fails (nonunion), a specific pattern of osteoarthritis occurs, resulting in a carpal collapse. It is unknown how a scaphoid nonunion influences carpal kinematics and results into this carpal collapse. Until now, most research is done with the wrist in a steady state position. This thesis uses a new imaging technique: four-dimensional (4D)-CT imaging, which can analyze scaphoid kinematics during wrist motion. Part one of this thesis contains two reviews which addressed the main issues of the imaging techniques currently used in patients with a scaphoid nonunion. The first chapter evaluates static CT-imaging, the second reviewed dynamic imaging techniques. Part II contains two papers, the first systematically evaluated clinical 4D-CT protocols, and the second systematically evaluated the error in positioning a coordinate system when scanning a shortened radial shaft. Part III addressed the results of two clinical trials and a trial protocol which applied the 4D-CT analysis technique in participants. The healthy carpal motion patterns between the scaphoid and lunate were evaluated in the first chapter. In the second chapter the effect of a scaphoid nonunion on carpal kinematics was described. The third paper describes a prospective trial protocol on acute scaphoid fractures. The final chapters of the thesis provides a general discussion, future perspectives and summary.
AB - The human wrist contains eight carpal bones in which the scaphoid plays a key role in carpal stability and mechanics. A scaphoid fracture is the most common carpal fracture. When healing of the fracture fails (nonunion), a specific pattern of osteoarthritis occurs, resulting in a carpal collapse. It is unknown how a scaphoid nonunion influences carpal kinematics and results into this carpal collapse. Until now, most research is done with the wrist in a steady state position. This thesis uses a new imaging technique: four-dimensional (4D)-CT imaging, which can analyze scaphoid kinematics during wrist motion. Part one of this thesis contains two reviews which addressed the main issues of the imaging techniques currently used in patients with a scaphoid nonunion. The first chapter evaluates static CT-imaging, the second reviewed dynamic imaging techniques. Part II contains two papers, the first systematically evaluated clinical 4D-CT protocols, and the second systematically evaluated the error in positioning a coordinate system when scanning a shortened radial shaft. Part III addressed the results of two clinical trials and a trial protocol which applied the 4D-CT analysis technique in participants. The healthy carpal motion patterns between the scaphoid and lunate were evaluated in the first chapter. In the second chapter the effect of a scaphoid nonunion on carpal kinematics was described. The third paper describes a prospective trial protocol on acute scaphoid fractures. The final chapters of the thesis provides a general discussion, future perspectives and summary.
UR - https://pure.uva.nl/ws/files/50695346/Licentieovereenkomst_medeondertekend_.pdf
UR - https://pure.uva.nl/ws/files/50695348/MGA_de_Roo_overzicht_verschillen_manuscript_als_beoordeeld_door_promotiecommissie_Four_Dimensional_Imaging_of_Scaphoid_kinematics.pdf
UR - https://pure.uva.nl/ws/files/50695350/Stellingen.pdf
M3 - Phd-Thesis - Research and graduation internal
SN - 9789464024869
ER -